The Effects of High Sucrose or High Fat Diet on Brain Macrostructure, Cognition, and Expression of Phosphorylated Tau

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atmire.migration.oldid4607
dc.contributor.advisorBorgland, Stephanie
dc.contributor.authorMackie, Yasmine Olga
dc.date.accessioned2016-07-08T16:41:10Z
dc.date.available2016-07-08T16:41:10Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractConsumption of sucrose-rich and fat-rich foods poses an in increased risk of obesity, and has been shown to be associated with cognitive decline, reduced cortical volume, and dementia. The goal of this thesis was to determine the effect of diet on metabolic measures, gut microbiota, brain macrostructure, cognitive function, and dementia biomarker expression in middle-aged female mice. In Chapter 2, high sucrose diet exposure did not alter metabolism, but increased liver triglyceride concentration and altered gut microbiota relative abundance. We also show that sucrose fed mice experienced a significant decrease in the volume of the parietal temporal cortex, and a deficit in cognitive flexibility. In Chapter 3, high fat diet exposure induced significant differences in weight, glucose sensitivity and plasma leptin levels, without altering the expressions of phosphorylated tau. Together, these studies demonstrate that diet, without affecting metabolic measures, can alter cortical volume and cognitive function.en_US
dc.identifier.citationMackie, Y. O. (2016). The Effects of High Sucrose or High Fat Diet on Brain Macrostructure, Cognition, and Expression of Phosphorylated Tau (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28107en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28107
dc.identifier.urihttp://hdl.handle.net/11023/3113
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.titleThe Effects of High Sucrose or High Fat Diet on Brain Macrostructure, Cognition, and Expression of Phosphorylated Tau
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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