Evaluation of in vitro contact lens friction: Effects of recombinant human proteogrlycan 4 and test counterface

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dc.contributor.advisorSchmidt, Tannin
dc.contributor.authorChan, Amanda
dc.contributor.committeememberRinker, Kristina
dc.contributor.committeememberEgberts, Philip
dc.date2018-02
dc.date.accessioned2018-01-19T00:43:04Z
dc.date.available2018-01-19T00:43:04Z
dc.date.issued2017-12-15
dc.description.abstractIn vitro contact lenses friction significantly correlates with contact lens discomfort. In this thesis, in vitro friction testing was conducted to evaluate the effects of recombinant human PRG4 (rhPRG4) as an ocular surface boundary lubricant and to evaluate both biological and synthetic test counterfaces. The objectives were to (1) assess the potential effect of different lens types and incubation times on the friction of rhPRG4-incubated contact lenses and (2) evaluate mucin- soaked PDMS as a synthetic test counterface for in vitro friction testing of contact lenses. Results of this thesis work demonstrated that a) rhPRG4 may be useful as a friction reducing lubricant on some, but not all, silicone hydrogel contact lenses; and b) as a synthetic counterface, PDMSmucin can exhibit similar friction coefficients compared to biological counterfaces on certain silicone hydrogel lenses. Overall, results led to an improved understanding of PRG4 and in vitro contact lens friction.en_US
dc.identifier.citationChan, A. C. Y. (2017). Evaluation of in vitro contact lens friction: Effects of recombinant human proteoglycan 4 and test counterface (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/5357en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/5357
dc.identifier.urihttp://hdl.handle.net/1880/106276
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultySchulich School of Engineering
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectOcular friction
dc.subjectContact lenses
dc.subjectBiotribology
dc.subjectBiomaterials
dc.subjectBiomedical devices
dc.subjectProteoglycan 4
dc.subject.classificationEngineering--Biomedicalen_US
dc.titleEvaluation of in vitro contact lens friction: Effects of recombinant human proteogrlycan 4 and test counterface
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.checklistI confirm that I have submitted all of the required forms to Faculty of Graduate Studies.en_US
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