Evaluation of in vitro contact lens friction: Effects of recombinant human proteogrlycan 4 and test counterface

Chan, Amanda

Evaluation of in vitro contact lens friction: Effects of recombinant human proteogrlycan 4 and test counterface

dc.contributor.advisor	Schmidt, Tannin
dc.contributor.author	Chan, Amanda
dc.contributor.committeemember	Rinker, Kristina
dc.contributor.committeemember	Egberts, Philip
dc.date	2018-02
dc.date.accessioned	2018-01-19T00:43:04Z
dc.date.available	2018-01-19T00:43:04Z
dc.date.issued	2017-12-15
dc.description.abstract	In vitro contact lenses friction significantly correlates with contact lens discomfort. In this thesis, in vitro friction testing was conducted to evaluate the effects of recombinant human PRG4 (rhPRG4) as an ocular surface boundary lubricant and to evaluate both biological and synthetic test counterfaces. The objectives were to (1) assess the potential effect of different lens types and incubation times on the friction of rhPRG4-incubated contact lenses and (2) evaluate mucin- soaked PDMS as a synthetic test counterface for in vitro friction testing of contact lenses. Results of this thesis work demonstrated that a) rhPRG4 may be useful as a friction reducing lubricant on some, but not all, silicone hydrogel contact lenses; and b) as a synthetic counterface, PDMSmucin can exhibit similar friction coefficients compared to biological counterfaces on certain silicone hydrogel lenses. Overall, results led to an improved understanding of PRG4 and in vitro contact lens friction.	en_US
dc.identifier.citation	Chan, A. C. Y. (2017). Evaluation of in vitro contact lens friction: Effects of recombinant human proteoglycan 4 and test counterface (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/5357	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/5357
dc.identifier.uri	http://hdl.handle.net/1880/106276
dc.language.iso	eng
dc.publisher.faculty	Graduate Studies
dc.publisher.faculty	Schulich School of Engineering
dc.publisher.institution	University of Calgary	en
dc.publisher.place	Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Ocular friction
dc.subject	Contact lenses
dc.subject	Biotribology
dc.subject	Biomaterials
dc.subject	Biomedical devices
dc.subject	Proteoglycan 4
dc.subject.classification	Engineering--Biomedical	en_US
dc.title	Evaluation of in vitro contact lens friction: Effects of recombinant human proteogrlycan 4 and test counterface
dc.type	master thesis
thesis.degree.discipline	Biomedical Engineering
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.item.requestcopy	true
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