Pendulum Study: Active Visual Tracking Elicits Non-Selective Elevations in Cerebral Blood Flow

Hodge, Sarah V. L.; Spence, Emma E. M.; Suraj, Rejitha; McGirr, Alexander; Phillips, Aaron Alexander

Pendulum Study: Active Visual Tracking Elicits Non-Selective Elevations in Cerebral Blood Flow

dc.contributor.author	Hodge, Sarah V. L.
dc.contributor.author	Spence, Emma E. M.
dc.contributor.author	Suraj, Rejitha
dc.contributor.author	McGirr, Alexander
dc.contributor.author	Phillips, Aaron Alexander
dc.date.accessioned	2019-11-26T22:24:03Z
dc.date.available	2019-11-26T22:24:03Z
dc.date.issued	2019-04
dc.description.abstract	Neurovascular coupling (NVC) describes the effective matching of cerebral blood flow (CBF) to regions of neuro-metabolic demand. There is increasing interest to assess human NVC for both basic research and its potential role in vascular-cognitive impairment. The clinical utility of NVC relies on a standardized protocol for which the driving metabolic demands are highly-selective. Various research groups deploy divergent strategies to elicit visual NVC responses, including inactive processes (visual grating), passive visual tracking (target with predictable motion) and active visual tracking (target with unpredictable motion). These strategies differ in degree of cognitive and metabolic demand and may elicit different NVC responses, thus precluding study comparison. The present NVC assessment evaluated temporal and regional responsiveness of blood flow (transcranial Doppler) to the visual cortex [via the posterior cerebral artery (PCA)] and blood pressure (Finapres NOVA) during visual stimulation in 19 healthy subjects while also measuring middle cerebral artery (MCA) blood flow. Visual stimulation included 10 cycles of 30 seconds with eyes closed, followed by 30 seconds with eyes open tracking a moving computerized target. Each subject completed three trials of passive tracking and three trials of active tracking (114 NVC protocols, 1140 individual hyperemias). A custom eye-scanning apparatus followed eye motion to quantify visual target-tracking vigilance. Additional custom software was used to quantify NVC. The data demonstrated that active tracking elicited greater NVC responses compared to passive tracking. Specifically, there was 26% greater change in the mean elevation of PCA blood velocity (p=<0.000) and 13% greater peak NVC response (p<0.01). The MCA response was also greater during active tracking (mean response 111% greater, peak response 41% greater; both p<0.001). Visual target-tracking vigilance was linearly correlated to the degree of hyperemia in the MCA and PCA, as well blood pressure during NVC. It was observed that active and passive visual tracking elicit different NVC responses and cannot be reliably compared. That PCA and MCA responses were greater with active tracking suggests an elevated global CBF (i.e. not selective to regions perfused by the PCA) that may result from recruitment of brain centres responsible for sustained attention and executive function. In other words, active tracking leads to non-selective elevations in global CBF and greater target-tracking vigilance impacts the NVC response. These findings are a critical step to better understand and standardize the evaluation of NVC in humans and for potential clinical deployment of NVC assessments.	en_US
dc.identifier.citation	Hodge, S. V. L., Spence, E. E. M., Suraj, R., McGirr, A., & Phillips, A. A. (2019). "Pendulum Study: Active Visual Tracking Elicits Non-Selective Elevations in Cerebral Blood Flow". University of Calgary, Calgary, AB.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/37271
dc.identifier.uri	http://hdl.handle.net/1880/111251
dc.language.iso	eng	en_US
dc.publisher.department	Physiology & Pharmacology	en_US
dc.publisher.faculty	Cumming School of Medicine	en_US
dc.publisher.institution	University of Calgary	en_US
dc.subject	Cerebral blood flow	en_US
dc.subject	Neuronal activation	en_US
dc.subject	Functional hyperemia	en_US
dc.subject	Neurovascular coupling	en_US
dc.title	Pendulum Study: Active Visual Tracking Elicits Non-Selective Elevations in Cerebral Blood Flow	en_US
dc.type	conference poster	en_US
ucalgary.item.requestcopy	true	en_US