An Analysis of a Cohort of Surgical-Related Intra-Abdominal Sepsis with PIRO

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atmire.migration.oldid1085
dc.contributor.advisorDoig, Christopher James
dc.contributor.advisorStelfox, H. Tomas
dc.contributor.advisorFerland, Andre
dc.contributor.authorPosadas Calleja, Juan Gabriel
dc.date.accessioned2013-07-10T16:42:14Z
dc.date.available2013-11-12T08:00:14Z
dc.date.issued2013-07-10
dc.date.submitted2013en
dc.description.abstractIntroduction: Sepsis constitutes an important cause of morbidity and mortality; mortality in patients with intraabdominal sepsis remains high. The PIRO concept is a classification scheme for sepsis. Methods: Retrospective analysis of a prospective observational cohort. Results: 905 patients were analyzed. A PIRO score was developed including the following variables: age > 65 years, comorbidities, leukopenia, hypothermia, cardiovascular, renal, respiratory, and CNS failure, one point was given for each present feature. The mean PIRO score was significantly higher in nonsurvivors than in survivors (3.9 vs. 2.3 respectively, p < 0.0001). When the patients were distributed according PIRO scoring, mortality rate increased (p <0.0001). The aROC showed consistent mortality discrimination by PIRO score (0.80, 95%CI 0.79 to 0.83), outperforming APACHE II (0.72, 95%CI 0.68 to 0.75) and SOFA (0.72, 95%CI 0.68 to 0.76) p <0.0001. Conclusion: The PIRO score performed well as an ICU mortality predictor tool for surgical related intra-abdominal sepsis.men_US
dc.identifier.citationPosadas Calleja, J. G. (2013). An Analysis of a Cohort of Surgical-Related Intra-Abdominal Sepsis with PIRO (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24829en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24829
dc.identifier.urihttp://hdl.handle.net/11023/780
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subject.classificationSepsisen_US
dc.subject.classificationPIROen_US
dc.subject.classificationSeptic shocken_US
dc.subject.classificationSevere sepsisen_US
dc.subject.classificationSurgical sepsisen_US
dc.titleAn Analysis of a Cohort of Surgical-Related Intra-Abdominal Sepsis with PIRO
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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