Predicting Cognitive Decline in Patients with TIA and Minor Stroke

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atmire.migration.oldid4193
dc.contributor.advisorBarber, Philip
dc.contributor.authorMunir, Muhammad Amlish
dc.contributor.committeememberSmith, Eric
dc.contributor.committeememberFrayne, Richard
dc.date.accessioned2016-03-23T17:54:12Z
dc.date.available2016-03-23T17:54:12Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractDementia is an incurable neurocognitive disorder and recognizing early pathological biomarkers can help to predict future dementia. Transient Ischemic Attack (TIA) and minor stroke patients are at risk of dementia. We hypothesized that TIA and minor stroke patients experience higher brain atrophy rates and that baseline brain and hippocampal volumes may predict cognitive decline at 3 years. Our results suggest that TIA and minor stroke patients experienced a higher percent brain atrophy rate over 3 years compared to controls. Cognitive decline was observed at 3 years for tests assessing processing speed, and short and long delay free recall. Age was a predictor of decline in processing speed and time was a predictor for short and long delay free recall as well. Higher whole-brain atrophy and cognitive decline at 3 years suggests that TIA/minor stroke patients are a high-risk population for dementia.en_US
dc.identifier.citationMunir, M. A. (2016). Predicting Cognitive Decline in Patients with TIA and Minor Stroke (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27401en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27401
dc.identifier.urihttp://hdl.handle.net/11023/2866
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationTransient Ischemic Attacken_US
dc.subject.classificationMagnetic Resonance Imagingen_US
dc.subject.classificationCognitive Declineen_US
dc.subject.classificationMinor Strokeen_US
dc.subject.classificationWhole-Brain Atrophy Rateen_US
dc.subject.classificationHippocampal Volumeen_US
dc.subject.classificationFMRIB Software Libraryen_US
dc.titlePredicting Cognitive Decline in Patients with TIA and Minor Stroke
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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