Bronchial Thermoplasty and Airway Remodeling in Severe Asthma

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atmire.migration.oldid4561
dc.contributor.advisorKelly, Margaret
dc.contributor.authorLaing, Austin
dc.contributor.committeememberProud, David
dc.contributor.committeememberGreen, Francis
dc.contributor.committeememberAmrein, Matthias
dc.date.accessioned2016-06-29T21:39:19Z
dc.date.available2016-06-29T21:39:19Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractIncreased airway smooth muscle (ASM) is a characteristic of severe asthma and strongly associated with airway hyperresponsiveness. Bronchial Thermoplasty (BT) aims is a new technique in which heat is applied to the airway. We hypothesize that BT causes reduced ASM in patients with severe asthma. We investigated the effect of BT on the airway in patients with severe asthma, acute effects in a pig model and the effect of hyperthermia on ASM and bronchial epithelial cells. We found a significant reduction in ASM and goblet cells at 6 weeks and 1 year post-BT, respectively. Acute effects of BT in the pig airway suggested a sterile injury pattern. Exposure to 65oC produced morphological changes in ASM and epithelial cells. We conclude that there is evidence of ASM and goblet cell reduction in response to BT but further confirmation awaits full analysis of the study in asthmatics.en_US
dc.identifier.citationLaing, A. (2016). Bronchial Thermoplasty and Airway Remodeling in Severe Asthma (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25176en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25176
dc.identifier.urihttp://hdl.handle.net/11023/3089
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPathology
dc.subject.classificationPathologyen_US
dc.subject.classificationAsthmaen_US
dc.subject.classificationAirway Remodelingen_US
dc.subject.classificationBronchial Thermoplastyen_US
dc.titleBronchial Thermoplasty and Airway Remodeling in Severe Asthma
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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