The Origin of Force Increase in Actively Stretched Single Muscle Fibres

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atmire.migration.oldid5609
dc.contributor.advisorHerzog, Walter
dc.contributor.authorLiu, Shuyue
dc.date.accessioned2017-05-30T17:13:19Z
dc.date.available2017-05-30T17:13:19Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractTheoretically, at long sarcomere lengths (SLs) beyond myofilament overlap, only passive forces, produced by passive structural elements, are possible. However, previous studies showed a dramatic increase in force above the passive force when myofibrils were actively stretched beyond actin and myosin filament overlap. It has been suggested that titin might produce this increase in force, possibly by increasing its stiffness in a variety of ways. In this study, I used rabbit psoas single muscle fibres to investigate whether the increase in force observed after active stretch to a sarcomere length beyond myofilament overlap was caused by a passive component (titin) alone, or possibly some remnant cross-bridges that continue to contribute force in some unknown manner in muscle fibres. The results indicate that both passive and active components are contributing to this force increase in actively stretched single muscle fibres at an average sarcomere length beyond myofilament overlap.en_US
dc.identifier.citationLiu, S. (2017). The Origin of Force Increase in Actively Stretched Single Muscle Fibres (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28265en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28265
dc.identifier.urihttp://hdl.handle.net/11023/3843
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPhysiology
dc.subject.othermuscle contraction
dc.subject.otherresidual force enhancement
dc.titleThe Origin of Force Increase in Actively Stretched Single Muscle Fibres
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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