Plasma Metabolomics of Community Acquired Pneumonia (CAP) For Prognosis of Patients at Highest Risk of Mortality

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atmire.migration.oldid3375
dc.contributor.advisorWinston, Brent
dc.contributor.authorBanoei, Mohammad Mehdi
dc.date.accessioned2015-07-13T17:22:57Z
dc.date.embargolift2017-01-08T17:22:57Z
dc.date.issued2015-07-13
dc.date.submitted2015en
dc.description.abstractCommunity acquired pneumonia (CAP) is an acute disease with clinical features of lower respiratory tract infections. Early and accurate prognoses, and effective treatment, where possible, in the management of CAP are essential to decrease mortality. Metabolomic analysis is defined as the comprehensive study of low molecular-weight metabolites present in biological samples that enable the qualitative and/or quantitative measurement and analysis of multiple metabolites We showed the feasibility of metabolomics using nuclear magnetic resonance (NMR) spectroscopy, gas chromatography mass spectrometry (GC-MS) and direct infusion tandem mass spectrometry (DIMS/MS) as most common analytical platforms in association with multivariate statistical analysis to separate non-survivors and survivor of bacteria CAP and H1N1 pneumonia patients for prognosis of mortality. In conclusion, this study may not only be instrumental in predicting the mortality of CAP patients within 24 hours of hospitalization, but may also allow for the rapid identification of the infective organism in CAP.en_US
dc.description.embargoterms18 monthsen_US
dc.identifier.citationBanoei, M. M. (2015). Plasma Metabolomics of Community Acquired Pneumonia (CAP) For Prognosis of Patients at Highest Risk of Mortality (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27367en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27367
dc.identifier.urihttp://hdl.handle.net/11023/2354
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Molecular
dc.subjectHealth Care Management
dc.subjectBiochemistry
dc.subject.classificationMetabolomicsen_US
dc.subject.classificationPneumoniaen_US
dc.subject.classificationH1N1en_US
dc.subject.classificationCAPen_US
dc.subject.classificationPrognosis of Mortalityen_US
dc.titlePlasma Metabolomics of Community Acquired Pneumonia (CAP) For Prognosis of Patients at Highest Risk of Mortality
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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