Effects of Sleeve Gastrectomy and Ileal Transposition, Alone and in Combination, on Food Intake, Body Weight, Gut Hormones and Glucose Metabolism in Rats
| atmire.migration.oldid | 540 | |
| dc.contributor.advisor | Chelikani, Prasanth | |
| dc.contributor.author | Nausheen, Saima | |
| dc.date.accessioned | 2013-01-07T22:59:31Z | |
| dc.date.available | 2013-06-15T07:01:43Z | |
| dc.date.issued | 2013-01-07 | |
| dc.date.submitted | 2012 | en |
| dc.description.abstract | Gastric bypass surgeries for obesity are hypothesized to produce weight loss and improve diabetes by multiple mechanisms including gastric restriction and lower gut stimulation. The surgeries typically involve rearrangement of the fore-gut, hind-gut or both. We compared the effects of foregut (Sleeve Gastrectomy, SG), hindgut (Ileal Transposition; IT), both (SG+IT), or sham manipulations, on food intake, body weight and glucose tolerance in male SD rats. SG, IT and SGIT surgeries produced transient reduction in food intake and weight gain but improvements in glucose tolerance. SG, IT and SGIT surgeries increased plasma GLP-1 concentrations; IT and SGIT increased PYY concentrations. The protein abundance of key markers of glucose metabolism (e.g. GLUT4, AMPK, PKA, IRS-1) in muscle and adipose tissue were increased following SG, IT, or SGIT. Improvement in glycemic control following these surgeries appears to be independent of changes in weight and is likely due to enhanced lower gut stimulation. | en_US |
| dc.identifier.citation | Nausheen, S. (2013). Effects of Sleeve Gastrectomy and Ileal Transposition, Alone and in Combination, on Food Intake, Body Weight, Gut Hormones and Glucose Metabolism in Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25832 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/25832 | |
| dc.identifier.uri | http://hdl.handle.net/11023/389 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.faculty | Veterinary Medicine | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Physiology | |
| dc.subject.classification | Body Weight | en_US |
| dc.subject.classification | Glucose Metabolism | en_US |
| dc.subject.classification | Food Intake | en_US |
| dc.title | Effects of Sleeve Gastrectomy and Ileal Transposition, Alone and in Combination, on Food Intake, Body Weight, Gut Hormones and Glucose Metabolism in Rats | |
| dc.type | master thesis | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |