Effect of Indomethacin on Kidney Development in Postnatal Period in Rats

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atmire.migration.oldid4446
dc.contributor.advisorWade, Andrew
dc.contributor.advisorSmith, Francine
dc.contributor.authorBaba, Hayat
dc.date.accessioned2016-05-16T21:51:09Z
dc.date.available2016-05-16T21:51:09Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractNephrogenesis in the human ends by the 36th week of gestation. In premature infants, nephrogenesis is assumed to continue after birth. Indomethacin (NSAID) is commonly used to treat patent ductus arteriosus (PDA) in premature infants. We hypothesized that administration of indomethacin in the newborn rats would cause a reduction in glomerular number. Four dosegroups of rats (n=7 in each) were injected intraperitoneally with three different doses (0.1, 0.5, 1 mg/kg) of indomethacin or a saline control for 11 days after birth. At the endpoint, blood was collected to measure indomethacin plasma concentrations and kidneys were collected for morphological measurement. Stereological techniques were used to measure the glomerular number and volume in these animals. We observed no significant differences in glomerular number (p=0.39) and volume (p=0.98) between the different treated groups. In conclusion, administration of indomethacin, while the process of nephrogenesis is ongoing, does not significantly reduce/change the glomerular number.en_US
dc.identifier.citationBaba, H. (2016). Effect of Indomethacin on Kidney Development in Postnatal Period in Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25801en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25801
dc.identifier.urihttp://hdl.handle.net/11023/3014
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPsychology--Physiological
dc.subject.classificationKidney developmenten_US
dc.subject.classificationIndomethacin, NSAIDen_US
dc.subject.classificationnephrogenesisen_US
dc.titleEffect of Indomethacin on Kidney Development in Postnatal Period in Rats
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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