The Evaluation of the Rat Grimace Scale and Ultrasonic Vocalisations as Novel Pain Assessment Tools in Laboratory Rats

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atmire.migration.oldid2754
dc.contributor.advisorPang, Daniel
dc.contributor.authorDe Rantere, Debbie
dc.date.accessioned2014-11-14T19:07:49Z
dc.date.available2015-02-23T08:00:29Z
dc.date.issued2014-11-14
dc.date.submitted2014en
dc.description.abstractMeasuring pain in non-human mammals such as rodents is challenging. Recently, spontaneous behaviours including facial expression and ultrasonic vocalisation have been proposed as novel, alternative measures of pain. The goal of this research was to evaluate the applicability of ultrasonic vocalisations, and the Rat Grimace Scale (a recently developed facial expression pain scale) during gas exposure (for euthanasia purposes) and in models of inflammatory and incisional pain. First, I found that ultrasonic vocalisations were emitted during carbon dioxide, but not during isoflurane exposure. Secondly, the Rat Grimace Scale was able to detect inflammatory and incisional pain in rats. Additionally, the pain score obtained using the Rat Grimace Scale corresponded with the findings of a conventional nociceptive test using von Frey filaments. My work contributes to the further understanding of ultrasonic communicative behaviour and facial expression of rats experiencing pain and the application of grimace scales in in-vivo biomedical research.en_US
dc.identifier.citationDe Rantere, D. (2014). The Evaluation of the Rat Grimace Scale and Ultrasonic Vocalisations as Novel Pain Assessment Tools in Laboratory Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28137en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28137
dc.identifier.urihttp://hdl.handle.net/11023/1943
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectVeterinary Science
dc.subject.classificationPainen_US
dc.subject.classificationratsen_US
dc.subject.classificationRat Grimace Scaleen_US
dc.subject.classificationnociceptive testen_US
dc.subject.classificationultrasonic vocalisationsen_US
dc.titleThe Evaluation of the Rat Grimace Scale and Ultrasonic Vocalisations as Novel Pain Assessment Tools in Laboratory Rats
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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