Brain Development During Childhood and Adolescence

dc.contributor.advisorLebel, Catherine
dc.contributor.authorMah, Alyssa
dc.contributor.committeememberFrayne, Richard
dc.contributor.committeememberWei, Xing-Chang
dc.contributor.committeememberForkert, Nils
dc.contributor.committeememberDyck, Richard
dc.description.abstractBrain development is a combination of complex physiological changes, and various magnetic resonance imaging (MRI) techniques can help explain observed changes during development in vivo. Building upon observations from post-mortem studies, advancements in imaging and modelling techniques provide new means to further interpret the understanding of healthy brain development during childhood and adolescence. It is, however, a challenge to capture specific physiological changes, such as myelination, using MRI. This thesis uses MRI techniques – neurite orientation dispersion and density imaging (NODDI), inhomogenous magnetization transfer (ihMT), and multi-component driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) – that further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional techniques. Measures from NODDI, ihMT, and mcDESPOT suggest an increase in myelination and/or axonal packing during development from 0-13 years.en_US
dc.identifier.citationMah, A. (2016). Brain Development During Childhood and Adolescence (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from doi:10.11575/PRISM/25160en_US
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectHuman Development
dc.subject.classificationMagnetic Resonance Imagingen_US
dc.titleBrain Development During Childhood and Adolescence
dc.typemaster thesis Engineering of Calgary of Science (MSc)