Colonoscopy reduces colorectal cancer through the removal of pre-cancerous polyps, which exposes patients to potential adverse events. Endoscopic clips are used by practitioners to prevent delayed post-polypectomy bleeding. This thesis reports the results of two studies performed with the aim of evaluating the practice patterns and clinical efficacy of prophylactic clipping during polypectomy. A meta-analysis of randomized trials showed that prophylactic clipping is not efficacious in preventing delayed bleeding during routine polypectomy, especially among polyps < 10 mm. A large retrospective cohort study then described clinical parameters associated with clip usage. We demonstrated that use of clips increased over time in a high-volume outpatient endoscopy unit. Furthermore, a high degree of variability in clipping patterns existed between endoscopists, including among polyps < 10 mm, where no efficacy exists. Taken together, these results reveal an urgent need for effective knowledge translation to eliminate this ineffective and costly practice during routine polypectomy.