Mild Traumatic Brain Injury, Sleep, and Pain in Adolescence

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dc.contributor.advisorMychasiuk, Richelle
dc.contributor.authorChristensen, Jennaya
dc.contributor.committeememberAntle, Michael C.
dc.contributor.committeememberNoel, Melanie
dc.contributor.committeememberLebel, Catherine A.
dc.date2019-06
dc.date.accessioned2018-11-22T16:09:06Z
dc.date.available2018-11-22T16:09:06Z
dc.date.issued2018-11-14
dc.description.abstractThe child and adolescent age group exhibit the highest rates of traumatic brain injury (TBI), with mild TBI (mTBI) and repetitive mild TBI (RmTBI) accounting for a large proportion of these injuries. Adolescents represent a particularly high risk cohort for experiencing long-term post-traumatic deficits. During this critical development phase, dramatic changes in brain structure and organization coincide with important shifts in the sleep cycle, which predispose adolescents to sleep deprivation. Similarly, mTBI often leads to reports of varying levels of sleep problems, yet the role of post-traumatic sleep in post-concussive symptomology remains unclear. Therefore, it is possible that sleep deprivation in the post-traumatic period could be further exacerbating the deleterious effects of mTBI. The glymphatic system is the central nervous system’s (CNS) macroscopic waste clearance system. Importantly, this system removes neurotoxic waste, such as Tau and β-amyloid, from the CNS. Recent developments have determined that the glymphatic system is 90% more active during sleep states while being dramatically suppressed during wakefulness. Given that Tau and β-amyloid protein aggregates are pathological trademarks of the neurodegenerative disorders that are associated with RmTBI and that mTBI patients commonly report sleep problems, one would reason that a reduced glymphatic clearance function may play an imperative role in the development of the neurological deficits related to RmTBI. Chronic pain and sleep deprivation represent major health issues that plague adolescence. A bidirectional relationship exists between sleep and pain; however, emerging evidence suggests that sleep disturbances have a stronger influence on subsequent pain than vice versa. The neurobiological underpinnings of this relationship, particularly during adolescence, are poorly understood. Given the high prevalence of these health issues during adolescence and the debilitating effects they inflict on nearly every domain of development, it is crucial that we determine the neurobiological mechanisms fundamental to this relationship and identify potential therapeutic strategies.en_US
dc.identifier.citationChristensen, J. (2018). Mild traumatic brain injury, sleep, and pain in adolescence (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/34520en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/34520
dc.identifier.urihttp://hdl.handle.net/1880/109190
dc.language.isoeng
dc.publisher.facultyArts
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectTraumatic brain injury
dc.subjectMRI
dc.subjectadolescence
dc.subjectChronic pain
dc.subjectSleep
dc.subjectSleep deprivation
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPsychology--Behavioralen_US
dc.subject.classificationPsychology--Developmentalen_US
dc.subject.classificationPsychology--Experimentalen_US
dc.subject.classificationPsychology--Physiologicalen_US
dc.subject.classificationPsychobiologyen_US
dc.titleMild Traumatic Brain Injury, Sleep, and Pain in Adolescence
dc.typemaster thesis
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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