Investigating the changes in phagosomal function in Porcine Reproductive and Respiratory Syndrome Virus infection

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atmire.migration.oldid1554
dc.contributor.advisorYates, Robin
dc.contributor.authorChaudhuri, Sibapriya
dc.date.accessioned2013-09-27T19:21:51Z
dc.date.available2013-11-12T08:00:19Z
dc.date.issued2013-09-27
dc.date.submitted2013en
dc.description.abstractPorcine Reproductive and Respiratory Syndrome is one of the most economically devastating diseases of the swine industry and affects all swine producing countries worldwide. The disease is caused by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The virus is macrophage-tropic and infects tissue macrophages in the host animal. However, nothing is known about how the phagosome lumenal microenvironment in the macrophages may be modified in PRRSV infection. Such knowledge is crucial for understanding how microbicidal and antigen presentation functions of the macrophage may be compromised during PRRSV infection. The field of PRRSV biology also suffers from the dearth of existence of a good in vitro system for studying the virus biology in a methodical and reductionist fashion. This thesis establishes an in vitro system for studying PRRSV infection. Using this newly established in vitro system of PRRSV infection in porcine bone marrow derived macrophages, this study investigates how the phagosome microenvironment changes in porcine macrophages in PRRSV infection. This study also investigates how phagosome lumenal properties are modified in porcine alveolar macrophages isolated from PRRSV infected pregnant gilts.en_US
dc.identifier.citationChaudhuri, S. (2013). Investigating the changes in phagosomal function in Porcine Reproductive and Respiratory Syndrome Virus infection (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26637en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26637
dc.identifier.urihttp://hdl.handle.net/11023/1058
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectVeterinary Science
dc.subjectVirology
dc.subjectImmunology
dc.subject.classificationmacrophageen_US
dc.subject.classificationPRRSVen_US
dc.subject.classificationPhagosomeen_US
dc.titleInvestigating the changes in phagosomal function in Porcine Reproductive and Respiratory Syndrome Virus infection
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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