Localization of Zinc in the Circadian System and its Role in the Modulation of Circadian Responses to Light

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atmire.migration.oldid5247
dc.contributor.advisorAntle, Michael
dc.contributor.authorMoshirpour, Mahtab
dc.contributor.committeememberKurrasch, Deborah
dc.contributor.committeememberDyck, Richard
dc.contributor.committeememberLovic, Vedran
dc.date.accessioned2017-01-17T22:20:59Z
dc.date.available2017-01-17T22:20:59Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractZinc is found in multiple brain areas where it can act as a neuromodulator of postsynaptic receptors. There is evidence for the existence of zinc in the SCN as well as its vesicle transporter (ZnT3) in the retina. However, its presence in other circadian areas has not been examined. This study observed the anatomical distribution of zinc in the SCN and IGL as well as ZnT3 in the retinal ganglion cells that project to these areas. The role of zinc in photic entrainment was also examined. The IGL contained considerable amounts of zinc while ZnT3 was present in retinal cells that are able to project to the IGL. Nevertheless zinc in the IGL was not implicated in the photic entrainment pathway and the retina was shown not to be a necessary zinc input source. Together, these results present the first report of zinc in the IGL and circadian retinal projections.en_US
dc.identifier.citationMoshirpour, M. (2017). Localization of Zinc in the Circadian System and its Role in the Modulation of Circadian Responses to Light (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26778en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26778
dc.identifier.urihttp://hdl.handle.net/11023/3567
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Sciences
dc.subjectAnimal Physiology
dc.subjectNeuroscience
dc.subject.otherCircadian
dc.subject.otherZinc
dc.subject.otherSuprachiasmatic Nucleus
dc.subject.otherIntergeniculate Leaflet
dc.subject.otherMelanopsin
dc.subject.otherPhase Shift
dc.subject.otherEntrainment
dc.subject.otherganglion cells
dc.titleLocalization of Zinc in the Circadian System and its Role in the Modulation of Circadian Responses to Light
dc.typemaster thesis
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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