Neurochemical Correlates of Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder

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dc.contributor.advisorClimie, Emma A.
dc.contributor.advisorMacMaster, Frank P.
dc.contributor.authorHai, Tasmia Mobashera
dc.contributor.committeememberWilcox, Gabrielle
dc.contributor.committeememberProtzner, Andrea B.
dc.date2018-11
dc.date.accessioned2018-10-05T16:06:41Z
dc.date.available2018-10-05T16:06:41Z
dc.date.issued2018-09-17
dc.description.abstractThe current study investigated spectroscopic biomarkers in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and examined neurochemical correlates of Executive Function (EF). Proton Magnetic Resonance Spectroscopy (1H-MRS; TE = 30ms) was conducted in the right prefrontal cortex (RPFC) and left striatum (LS). Twenty-one children with ADHD and 15 control participants took part. Both groups completed performance-based EF tasks. Results indicated lower concentrations of glutamate (p = .009), choline (p = .016), and N-acetyl aspartate (p = .029) in the RPFC in ADHD participants compared to controls. There were no significant differences in the LS. Positive correlations with glutamate concentration and performance in working memory and verbal fluency tasks in the control group were observed. No significant correlations were found in the ADHD group. Findings indicate neurochemical differences between children with ADHD and healthy controls. Additionally, decoupling effects of glutamate were observed indicating glutamate as a possible spectroscopic biomarker for ADHD and novel treatment target.en_US
dc.identifier.citationHai, T. M. (2018). Neurochemical Correlates of Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/33119en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33119
dc.identifier.urihttp://hdl.handle.net/1880/108767
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyWerklund School of Education
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectADHD
dc.subjectGLUTAMATE
dc.subjectEXECUTIVE FUNCTIONS
dc.subjectMAGNETIC RESONANCE SPECTROSCOPY
dc.subjectbiomarkers
dc.subject.classificationEducational Psychologyen_US
dc.titleNeurochemical Correlates of Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder
dc.typemaster thesis
thesis.degree.disciplineEducational Psychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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