In Silico Studies of Peptide-Peptide Interactions: Relevance to Amyloid Beta Peptide Aggregation in Alzheimer’s Disease

Simple item page
atmire.migration.oldid4455
dc.contributor.advisorRauk, Arvi
dc.contributor.authorPetoyan, Anahit
dc.contributor.committeememberTieleman, Peter
dc.contributor.committeememberKusalik, Peter
dc.contributor.committeememberNoskov, Sergei
dc.date.accessioned2016-05-18T21:49:52Z
dc.date.available2016-05-18T21:49:52Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractAlzheimer's disease is a progressive, chronic fatal disease of the brain where the amyloid beta (Aβ) peptide appears in its oligomeric forms, which are known to be neurotoxic. One way to stop this neurotoxicity is to prevent self-oligomerization of Aβ peptide. In the literature, it was shown that Aβ binds to itself in the region of Aβ (13-23) referred as the self-recognition site (Rec). In our lab, several pseudopeptides (referred as Ligands) were designed to bind with Aβ (13-23). Computational chemistry techniques such as Molecular Dynamics Simulations and Umbrella Sampling have been utilized to characterize the Ligands that are intended to bind selectively to the Rec. It has been observed that the Ligands bind to Rec, Aβ (13-23), and they are competitive with it, suggesting that these Ligands can compete with the full length of Aβ as well. Thus, they could be considered as “drug” candidates to stop Aβ oligomerization.en_US
dc.identifier.citationPetoyan, A. (2016). In Silico Studies of Peptide-Peptide Interactions: Relevance to Amyloid Beta Peptide Aggregation in Alzheimer’s Disease (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26552en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26552
dc.identifier.urihttp://hdl.handle.net/11023/3025
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectChemistry
dc.subject.classificationAlzheimer's Diseaseen_US
dc.subject.classificationAbeta Aggregationen_US
dc.subject.classificationPeptide-Peptide Interactionsen_US
dc.subject.classificationOligomerizationen_US
dc.titleIn Silico Studies of Peptide-Peptide Interactions: Relevance to Amyloid Beta Peptide Aggregation in Alzheimer’s Disease
dc.typemaster thesis
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations