Resting State Functional Connectivity in People at Clinical High Risk for Psychosis

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atmire.migration.oldid1151
dc.contributor.advisorAddington, Jean
dc.contributor.authorAbraham, Nachum
dc.date.accessioned2013-07-15T22:18:07Z
dc.date.available2013-11-12T08:00:16Z
dc.date.issued2013-07-15
dc.date.submitted2013en
dc.description.abstractNeuroimaging studies in participants at clinical high risk (CHR) for psychosis may provide evidence into the etiology of psychosis. Abnormalities in connectivity have been reported in schizophrenia but little is known about resting state functional connectivity (RSFC) prior to the onset of psychosis. The aim of this project was to identify functional neuroimaging markers for individuals at CHR. It was hypothesized that each network investigated, including the default mode, salience, executive control and dorsal attention network, would show aberrant connectivity in the CHR sample. Thirty-­one CHR participants who met Criteria of Prodromal Syndromes and 12 healthy controls (HC) were scanned using resting-­state fMRI. Seed‐based region-­of­‐interest correlation analysis was used to identify the default mode, salience, executive control, and dorsal attention networks. Compared to HC, people at CHR demonstrated aberrancies in all four resting state networks that were tested. Results indicated resting state networks have altered patterns of connectivity in people at CHR for psychosis, when compared to HC. Each network tested was differentially affected. Aberrancies in RSFC suggest that functional specialization is altered in individuals at CHR who, in turn, may have difficulty properly allocating attentional resources between internal and external stimuli, even prior to the onset of psychosis.en_US
dc.identifier.citationAbraham, N. (2013). Resting State Functional Connectivity in People at Clinical High Risk for Psychosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27654en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27654
dc.identifier.urihttp://hdl.handle.net/11023/829
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMental Health
dc.subjectPsychology--Clinical
dc.subject.classificationClinical High Risken_US
dc.subject.classificationResting stateen_US
dc.subject.classificationfunctional connectivityen_US
dc.subject.classificationDefault mode networken_US
dc.titleResting State Functional Connectivity in People at Clinical High Risk for Psychosis
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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