dc.contributor.author	Hill, Alexander
dc.contributor.author	Gailer, Juergen
dc.date.accessioned	2021-09-10T21:21:46Z
dc.date.available	2021-09-10T21:21:46Z
dc.date.issued	2020-10-05
dc.description.abstract	The chronic exposure of human populations to toxic metals remains a global public health concern. Although chronic Cd exposure is linked to kidney damage, osteoporosis and cancer, the underlying biomolecular mechanisms remain incompletely understood. Since other diseases could also be causally linked to chronic Cd exposure, a systems toxicology-based approach is needed to gain new insight into the underlying exposure-disease relationship. This approach requires one to integrate the cascade of dynamic bioinorganic chemistry events that unfold in the bloodstream after Cd enters with toxicological events that unfold in target organs over time. To this end, we have conducted a systematic literature search to identify all molecular targets of Cd in plasma and in red blood cells (RBCs). Based on this information it is impossible to describe the metabolism of Cd and the toxicological relevance of it binding to molecular targets in/on RBCs is elusive. Perhaps most importantly, the role that peptides, amino acids and inorganic ions, including HCO3-, Cl- and HSeO3- play in terms of mediating the translocation of Cd to target organs and its detoxification is poorly understood. Causally linking human exposure to this metal with diseases requires a much better integration of the bioinorganic chemistry of Cd that unfolds in the bloodstream with target organs. This from a public health point of view important goal will require collaborations between scientists from different disciplines to untangle the complex mechanisms which causally link Cd exposure to disease.	en_US
dc.description.grantingagency	Natural Sciences and Engineering Research Council (NSERC)	en_US
dc.identifier.citation	Hill, A., & Gailer, J. (2020). Linking molecular targets of Cd in the bloodstream to organ-based adverse health effects. Journal of Inorganic Biochemistry, 111279.	en_US
dc.identifier.doi	https://doi.org/10.1016/j.jinorgbio.2020.111279	en_US
dc.identifier.uri	http://hdl.handle.net/1880/113842
dc.language.iso	eng	en_US
dc.publisher	Elsevier	en_US
dc.publisher.department	Chemistry	en_US
dc.publisher.faculty	Science	en_US
dc.publisher.hasversion	acceptedVersion	en_US
dc.publisher.institution	University of Calgary	en_US
dc.publisher.policy	https://www.elsevier.com/open-access	en_US
dc.rights	Unless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	Cd exposure	en_US
dc.subject	bloodstream	en_US
dc.subject	molecular target	en_US
dc.subject	bioinorganic chemistry	en_US
dc.subject	target organs	en_US
dc.subject	disease	en_US
dc.title	Linking molecular targets of Cd in the bloodstream to organ-based adverse health effects	en_US
dc.type	journal article	en_US
ucalgary.item.requestcopy	true	en_US
ucalgary.scholar.level	Faculty	en_US

Linking molecular targets of Cd in the bloodstream to organ-based adverse health effects

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