Effects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats

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atmire.migration.oldid1354
dc.contributor.advisorReimer, Raylene
dc.contributor.authorDennison, Carol
dc.date.accessioned2013-09-13T18:23:57Z
dc.date.available2013-11-12T08:00:11Z
dc.date.issued2013-09-13
dc.date.submitted2013en
dc.description.abstractThe objective of this study was to determine if a combined oligofructose and sitagliptin pre-pregnancy intervention could mitigate the decreased fecundity, poor pregnancy outcomes and negative offspring health outcomes associated with maternal obesity. Obese female Sprague-Dawley rats were randomized to 1 of 6 groups: 1) AIN-93 (Control-Treated Obese); 2) OFS (Fibre-Treated Obese); 3) Sitagliptin (Drug-Treated Obese); 4) OFS+Sitagliptin (Combination-Treated Obese); 5) Caloric restriction (Weight-Matched to group 4), 6) High fat & sucrose (Obese Untreated). A lean reference group was also included. Pups consumed a HFS diet for 6 weeks in adulthood. Reduced blood glucose was seen in sitagliptin offspring and increased short-chain fatty acid receptor expression and Bifidobacteria seen in offspring of the combination treated dams. Despite these changes, the pre-pregnancy treatments investigated in this study did not lead to meaningful improvements in maternal fecundity, pregnancy outcomes or offspring health.en_US
dc.identifier.citationDennison, C. (2013). Effects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25816en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25816
dc.identifier.urihttp://hdl.handle.net/11023/956
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectHuman Development
dc.subjectNutrition
dc.subject.classificationFetal Programmingen_US
dc.subject.classificationObesityen_US
dc.titleEffects of a Maternal Pre-pregnancy Dietary and Pharmacological Intervention on Maternal Fecundity and Offspring Health in Sprague-Dawley Rats
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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