Oxygen Sensing in Lymnaea: from Behaviour to Central Pattern Generators

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atmire.migration.oldid4163
dc.contributor.advisorSyed, Naweed I.
dc.contributor.authorJanes, Tara Adele
dc.contributor.committeememberGoldberg, Jeff
dc.contributor.committeememberWhelan, Patrick
dc.date.accessioned2016-02-02T20:25:47Z
dc.date.available2016-02-02T20:25:47Z
dc.date.issued2016-02-02
dc.date.submitted2016en
dc.description.abstractFrom invertebrates to humans, the regulation of cellular O2 levels within narrow physiological limits represents a significant challenge, but one that is necessary for survival. This essential task of O2 homeostasis is controlled by the nervous system so as to meet metabolic O2 demands in the face of ever-changing environments or injury/disease. The process by which the nervous system exercises such precise control over systemic O2 levels is termed respiratory behaviour. Specialized neural circuits termed respiratory central pattern generators (rCPG’s) produce the basic rhythmic motor output underlying respiratory behaviour. In turn, rCPG activity is subject to extensive neuromodulation, which allows respiratory behaviour to be adapted to changing environments or during various disease states. However, the fundamental mechanisms by which rCPG networks collect and integrate sensory information about the O2 environment and orchestrate a diversity of adaptive behavioural responses remains poorly understood. Specifically, data characterizing the effect of graded hypoxia on respiratory behaviour, locomotion and breathing pattern have not been described for many invertebrate taxa. These data are important as they aid our understanding of fundamental network mechanisms in metazoan respiratory control. Furthermore, while O2 chemoreceptors have been shown to be critical for rCPG modulation and adaptation to hypoxia, the mechanisms of hypoxic signal transduction and O2-sensing, as well as the functional relationship between multiple peripheral and central chemoreceptors remains uncertain. This thesis has sought to fill these gaps in our knowledge using the Lymnaea stagnalis model system wherein the neural correlates of aerial respiratory behaviour have been previously defined. Here, I demonstrate how graded environmental hypoxia produces adaptive changes in Lymnaea aerial respiratory behaviour by altering respiratory parameters, breathing pattern and plasticity. Moreover, I have identified a distributed peripheral O2 chemoreceptive network, which provides significant modulation of rCPG activity. Finally, I have defined the ability of central hypoxia to modulate rCPG activity and connectivity. Taken together, these studies fill significant gaps in fundamental knowledge vis-à-vis the mechanisms by which highly plastic respiratory neural networks collect and integrate information about the O2 environment in order to produce adaptive respiratory behaviour.en_US
dc.identifier.citationJanes, T. A. (2016). Oxygen Sensing in Lymnaea: from Behaviour to Central Pattern Generators (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27243en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27243
dc.identifier.urihttp://hdl.handle.net/11023/2809
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectNeuroscience
dc.subject.classificationcentral pattern generatorsen_US
dc.subject.classificationchemoreceptionen_US
dc.subject.classificationhypoxiaen_US
dc.subject.classificationLymnaea stagnalisen_US
dc.titleOxygen Sensing in Lymnaea: from Behaviour to Central Pattern Generators
dc.typedoctoral thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.item.requestcopytrue
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