Sex Differences in Parvalbumin Inhibitory Interneurons in the Mouse Retrosplenial Cortex

Simple item page
dc.contributor.advisorEpp, Jonathan
dc.contributor.authorKhiabanian, Nadia Khoshbaf
dc.contributor.committeememberBarha, Cindy
dc.contributor.committeememberKuipers, Hedwich
dc.date2024-11
dc.date.accessioned2024-07-03T20:06:46Z
dc.date.available2024-07-03T20:06:46Z
dc.date.issued2024-07-02
dc.description.abstractParvalbumin inhibitory interneurons (PV-INs) are a crucial subclass of cortical interneurons, essential for maintaining excitatory/inhibitory (E/I) balance. Disruptions in E/I balance can impair learning, memory, and normal brain function. PV-INs are particularly susceptible to various insults, potentially leading to pathological conditions such as schizophrenia, epilepsy, autism, and Alzheimer's disease. However, the role of PV-INs in these disorders is not fully understood. Our research has identified sex differences in the vulnerability of retrosplenial cortex (RSC) PV-INs under conditions like Alzheimer's disease, traumatic brain injury, and early life stress. This study aims to investigate sex differences in PV-IN characteristics under normal healthy condition—such as number, connectivity, and function—in the RSC of healthy mice, which may underlie differential vulnerability between sexes. Here, we found that both female and male mice exhibit similar RSC neuronal activity levels, indicating no impairment. However, female mice have fewer PV-INs compared to males, and their PV-INs are less frequently surrounded by protective perineuronal nets. Additionally, female PV-INs have more presynaptic contacts per cell than males. This suggests a compensatory mechanism in females, where lower PV-IN numbers with increased synaptic connections allow them to maintain equivalent levels of inhibition. This pattern indicates that despite fewer PV-INs, females may have adaptive advantages that mitigate the impact of reduced PV-IN numbers, contributing to their resilience against certain pathological conditions.
dc.identifier.citationKhiabanian, N. K. (2024). Sex differences in parvalbumin inhibitory interneurons in the mouse retrosplenial cortex (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/119090
dc.identifier.urihttps://doi.org/10.11575/PRISM/46686
dc.language.isoen
dc.publisher.facultyCumming School of Medicine
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectSex differences
dc.subjectLearning and memory
dc.subjectParvalbumin inhibitory interneurons
dc.subjectRetrosplenial cortex
dc.subject.classificationNeuroscience
dc.titleSex Differences in Parvalbumin Inhibitory Interneurons in the Mouse Retrosplenial Cortex
dc.typemaster thesis
thesis.degree.disciplineMedicine – Neuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2024_khoshbaf-khiabanian_nadia.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations