Spectro-temporal Receptive Fields Constructed on Neuronal Input and Output in the Auditory Cortex

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atmire.migration.oldid6096
dc.contributor.advisorYan, Jun
dc.contributor.authorBao, Xiaohan
dc.contributor.committeememberYan, Jun
dc.contributor.committeememberEggermont, Jos
dc.contributor.committeememberFrench, Robert
dc.contributor.committeememberDyck, Richard
dc.contributor.committeememberStell, William
dc.date.accessioned2017-10-03T18:13:17Z
dc.date.available2017-10-03T18:13:17Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractFrequency coding is a principal function of the auditory system. Frequency selectivity and level tolerances are reflected by the sharpness of frequency tuning, often quantified as frequency bandwidths. Along the ascending auditory pathway, spectral information of complex acoustic stimuli is progressively decomposed with higher-level subcortical nuclei evincing more sharply-tuned neurons. Auditory cortical neurons feature broad variation in bandwidths, due to convergent thalamocortical projections. Oppositely, cortical modulation characterized by input and output frequency receptive fields most likely acts by sharpening frequency tuning. Spectro-temporal receptive fields (STRFs) constructed on post-synaptic potential (PSP) amplitude and action potential (AP) firing rates were recorded from mouse auditory cortex layer IV neurons using in vivo whole-cell current-clamp without blocking voltage-dependent conductances. AP-based STRFs showed smaller bandwidths than PSP-based STRFs while frequency bandwidths increased with sound level using multi-frequency stimuli, but less so using single-frequency stimuli. Bandwidth ratios of PSP- and AP-based STRFs were reduced by raising sound level or stimulus density.en_US
dc.identifier.citationBao, X. (2017). Spectro-temporal Receptive Fields Constructed on Neuronal Input and Output in the Auditory Cortex (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27852en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27852
dc.identifier.urihttp://hdl.handle.net/11023/4198
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.titleSpectro-temporal Receptive Fields Constructed on Neuronal Input and Output in the Auditory Cortex
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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