Allogeneic Adipose-Derived Mesenchymal Stem Cells as an Adjunct to Endovascular Treatment of Intracranial Aneurysms

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dc.contributor.advisorMitha, Alim
dc.contributor.advisorSen, Arindom
dc.contributor.authorBelanger, Brooke Lynnae
dc.contributor.committeememberLiao, Shan
dc.contributor.committeememberUngrin, Mark
dc.date2023-11
dc.date.accessioned2023-07-21T17:03:33Z
dc.date.available2023-07-21T17:03:33Z
dc.date.issued2023-06
dc.description.abstractIntracranial aneurysms are a condition characterized by the weakening of blood vessels in the brain, affecting approximately 1 in 5 individuals. Rupture of these fragile blood vessels can result significant brain bleeding, also known as subarachnoid hemorrhage, leading to a stroke that can cause severe neurological deficits or death. Current treatment approaches involve either endovascular or open surgery. One of the most common treatments is endovascular surgery, a minimally invasive procedure that entails inserting a small catheter through the femoral or radial artery and navigating it to the location of the aneurysm in the brain. Depending on the anatomical features, the aneurysm sac is filled with small platinum coils, or a mesh metal stent which is placed to cover the aneurysm opening. The objective in both cases is to redirect blood flow and eliminate the risk of stroke. However, recurrent aneurysms occur in up to 30% of these procedures, necessitating multiple surgeries. Recent advancements have introduced novel endovascular devices such as bioresorbable stents to enhance the outcomes of aneurysm treatment. Additionally, allogeneic adult mesenchymal stem cells have shown promise in improving healing processes. This dissertation aims to expand our understanding of the impact of stem cells on aneurysm healing and how they can be effectively utilized to improve the outcomes of brain aneurysm treatments, including endovascular coiling and stenting.
dc.identifier.citationBelanger, B. L. (2023). Allogeneic adipose-derived mesenchymal stem cells as an adjunct to endovascular treatment of intracranial aneurysms (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/116777
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/41619
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectaneurysm
dc.subjectstem cells
dc.subject.classificationNeuroscience
dc.titleAllogeneic Adipose-Derived Mesenchymal Stem Cells as an Adjunct to Endovascular Treatment of Intracranial Aneurysms
dc.typedoctoral thesis
thesis.degree.disciplineMedicine – Neuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.thesis.accesssetbystudentI require a thesis withhold – I need to delay the release of my thesis due to a patent application, and other reasons outlined in the link above. I have/will need to submit a thesis withhold application.
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