Is Peripheral Neuropathy occurring in association with Idiopathic Parkinson's Disease, an iatrogenic complication?

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dc.contributor.advisorFeasby, Thomas Erskine
dc.contributor.authorPodgorny, Peter Jan
dc.date.accessioned2014-07-17T21:30:35Z
dc.date.available2014-11-17T08:00:39Z
dc.date.issued2014-07-17
dc.date.submitted2014en
dc.description.abstractIdiopathic Parkinson’s disease (PD) is primarily a movement disorder resulting from the degeneration of dopaminergic neurons within the basal ganglia. However, it is not known if changes occur in PD other than traditional motor signs and symptoms, manifesting as non-motor problems such as autonomic or sensory abnormalities. The additional involvement of the peripheral nervous system in PD has only recently gained appreciation, particularly with a higher prevalence of peripheral neuropathy (PN). The concomitant occurrence of PN in PD has prompted speculation about the cause of PN, whether it has been an overlooked phenomenon of PD or a side effect of treatment with levodopa. The current study will investigate the occurrence of PN in newly diagnosed PD patients not yet treated with levodopa. In addition to gold-standard tests for PN, including neurological physical examination and nerve conduction studies, we will study new and sensitive techniques namely corneal confocal microscopy and skin biopsy, to search for subclinical indications of PN occurring in this patient population.en_US
dc.identifier.citationPodgorny, P. J. (2014). Is Peripheral Neuropathy occurring in association with Idiopathic Parkinson's Disease, an iatrogenic complication? (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26681en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26681
dc.identifier.urihttp://hdl.handle.net/11023/1642
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMedicine and Surgery
dc.subject.classificationParkinson'sen_US
dc.subject.classificationNeuropathyen_US
dc.subject.classificationLevodopaen_US
dc.subject.classificationPeripheralen_US
dc.subject.classificationNervesen_US
dc.subject.classificationIatrogenicen_US
dc.titleIs Peripheral Neuropathy occurring in association with Idiopathic Parkinson's Disease, an iatrogenic complication?
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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