An Investigation of 53BP1 in Multiple Myeloma

Simple item page
atmire.migration.oldid5821
dc.contributor.advisorBahlis, Nizar
dc.contributor.authorSimms, Justin
dc.contributor.committeememberGoodarzi, Aaron
dc.contributor.committeememberLees-Miller, Susan
dc.date.accessioned2017-08-04T15:50:07Z
dc.date.available2017-08-04T15:50:07Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractCurrently, multiple myeloma is the second most common hematological malignancy, and as of yet it remains incurable. Although many therapeutic advances have been made in the recent past, there is still room for improvement in the treatment of myeloma. Here, using CRISPR/Cas9 genome editing, we show that a therapeutic combination of proteasome inhibition in combination with PARP inhibition that is in clinical trials depends on the DNA damage response protein 53BP1. These findings contribute to the understanding of the mechanisms behind potential resistance to the combination of proteasome inhibitors with PAPR inhibitors.en_US
dc.identifier.citationSimms, J. (2017). An Investigation of 53BP1 in Multiple Myeloma (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24911en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24911
dc.identifier.urihttp://hdl.handle.net/11023/4002
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subjectOncology
dc.titleAn Investigation of 53BP1 in Multiple Myeloma
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations