Hip Derived Synovial Mesenchymal Progenitor Cell Surface Markers In Situ as Indicators for Differentiation Potential

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atmire.migration.oldid4951
dc.contributor.advisorKrawetz, Roman
dc.contributor.authorAffan, Asmaa
dc.contributor.committeememberSen, Arindom
dc.contributor.committeememberPowell, Jim
dc.date.accessioned2016-09-28T22:05:34Z
dc.date.available2016-09-28T22:05:34Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe degeneration of articular cartilage observed in patients with osteoarthritic (OA) joints coupled with the lack of regenerative abilities of cartilage play a major role in causing disability in OA patients. The synovial membrane within the joints is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis (in vivo and in vitro). However, it remains unknown if these sMPCs express any markers in vivo/in situ that give information as to which of the specific MPC sub-populations have pro-chondrogenic capacity. In the patient cohort examined in this study, the most common cell surface marker profile on MPCs was determined to be CD90+/CD44+/CD73+, and though it included cells that had chondrogenic capacity, it also included cells that did not. Additional markers are therefore required to further discriminate the heterogeneous populations of MPCs and identify synovial MPCs that are enriched for chondrogenic capacity.en_US
dc.identifier.citationAffan, A. (2016). Hip Derived Synovial Mesenchymal Progenitor Cell Surface Markers In Situ as Indicators for Differentiation Potential (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26371en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26371
dc.identifier.urihttp://hdl.handle.net/11023/3349
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEngineering--Biomedical
dc.subject.classificationmesenchymal stem cellsen_US
dc.subject.classificationtissue engineeringen_US
dc.subject.classificationsynoviumen_US
dc.titleHip Derived Synovial Mesenchymal Progenitor Cell Surface Markers In Situ as Indicators for Differentiation Potential
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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