Equine Glandular Gastric Disease: Prevalence and Potential Mechanisms of Formation

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atmire.migration.oldid5795
dc.contributor.advisorBanse, Heidi
dc.contributor.advisorCribb, Alastair
dc.contributor.authorPedersen, Sarah Kate
dc.contributor.committeememberRead, Emma
dc.contributor.committeememberFrench, Daniel
dc.contributor.committeememberMcCafferty, Donna-Marie
dc.date.accessioned2017-07-18T17:20:15Z
dc.date.available2017-07-18T17:20:15Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractThe pathophysiology of and risk factors for equine glandular gastric disease (EGGD) formation are poorly understood. The present studies aimed to explore risk factors for spontaneous EGGD, and evaluate the role of prostaglandin synthesis in NSAID-induced gastric glandular disease formation. In a population of 86 show jumping Warmblood horses, prevalence of EGGD grade ≥2 was 49%. Competing at the national level was the risk factor identified in the multivariable analysis for grade ≥2 EGGD. In order to evaluate the role of prostaglandin concentration in NSAID-induced EGGD, twelve horses were treated with either phenylbutazone or placebo for one week. Glandular disease score increased in the phenylbutazone group. Prostaglandin concentrations in glandular gastric biopsies increased over time in both treatment groups. In summary, competition level appears to be a risk factor for spontaneous EGGD. Decreased prostaglandin concentration does not appear to be a primary contributor to NSAID-induced EGGD.en_US
dc.identifier.citationPedersen, S. K. (2017). Equine Glandular Gastric Disease: Prevalence and Potential Mechanisms of Formation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25932en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25932
dc.identifier.urihttp://hdl.handle.net/11023/3966
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectVeterinary Science
dc.subject.otherEquine
dc.subject.otherGlandular
dc.subject.otherDisease
dc.titleEquine Glandular Gastric Disease: Prevalence and Potential Mechanisms of Formation
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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