Cytotoxic, Cellular Uptake, and Photophysical Properties of Various Re(I) Tricarbonyl Complexes
Date
2019-09-20
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Abstract
A series of Re(I) tricarbonyl complexes with the general formula, fac-[Re(CO)3(2,2’-bipyridine)(X)]-/0 (X= L-cysteine; N-acetyl-L-cysteine; thiosulfate) were characterized using spectroscopic techniques and single-crystal X-ray diffraction. Photophysical, as well as singlet oxygen (1O2) generation and CO releasing properties were assessed. Cell viability of the complexes against the MDA-MB-231 breast cancer cell line were determined. Cellular localization and accumulation were investigated using synchrotron-based X-ray fluorescence microscopy (XFM). The results of this study show the cytotoxicity, cellular uptake and photophysical properties of fac-[Re(CO)3(bpy)X]+/0/- complexes (X= H2O, HCys-, NAC2-, S2O32-; bpy=2,2’-bipyridine). The cytotoxicity of fac-[Re(CO)3(bpy)(H2O)]+ is diminished when the aqua ligand is replaced by cysteine or thiosulfate.
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Keywords
cancer MDA-MB-231 singlet oxygen fluorescence cytotoxicity rhenium organometallics
Citation
Capper, M. S. (2019). Cytotoxic, Cellular Uptake, and Photophysical Properties of Various Re(I) Tricarbonyl Complexes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.