Morphology and Dental Function in a BMP7 Rodent Knockout Model and Implications for Mammalian Tooth Evolution

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atmire.migration.oldid4857
dc.contributor.advisorTheodor, Jessica
dc.contributor.advisorJamniczky, Heather
dc.contributor.authorZurowski, Chelsey
dc.contributor.committeememberRogers, Sean
dc.contributor.committeememberGraf, Daniel
dc.date.accessioned2016-09-06T15:29:51Z
dc.date.available2016-09-06T15:29:51Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractTooth morphology is the result of tissue interactions, many of which involve families of regulatory genes that pattern development. Determining and quantifying the effect of regulatory genes has implications for understanding the mechanisms driving the degree of diversity observed in mammalian dentition. Bone morphogenetic protein 7 (BMP7) is one regulatory gene that is active in the developing tooth. I characterized the morphology and assessed the function of the dentition in BMP7 conditional knockout mice. Mutant molars had short, broad cusps, and extra cusps on the M1 and m1. Wear facets in the mutant mice were different in shape and in the direction that they faced on the tooth. This shows that changes in the expression of BMP7 lead to changes in the morphology and function of the dentition, suggesting that BMP7 could have acted in structuring the amount of dental diversity that is apparent in extinct and extant mammals.en_US
dc.identifier.citationZurowski, C. (2016). Morphology and Dental Function in a BMP7 Rodent Knockout Model and Implications for Mammalian Tooth Evolution (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27008en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27008
dc.identifier.urihttp://hdl.handle.net/11023/3264
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology
dc.subjectAnatomy
dc.subjectEcology
dc.subjectZoology
dc.subjectPaleontology
dc.subject.classificationBone Morphogenetic Protein 7en_US
dc.subject.classificationTooth Evolutionen_US
dc.subject.classificationMammal Evolutionen_US
dc.subject.classificationTooth Developmenten_US
dc.subject.classificationBMP7en_US
dc.subject.classificationTooth Wearen_US
dc.subject.classificationDental Adaptationen_US
dc.titleMorphology and Dental Function in a BMP7 Rodent Knockout Model and Implications for Mammalian Tooth Evolution
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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