A Cross-Bridge Based Model of Force Depression: Can a Single Modification Address both Transient and Steady-State Behaviours?

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dc.contributor.authorHerzog, Walter
dc.contributor.authorCorr, David T.
dc.date.accessioned2016-06-22T18:54:39Z
dc.date.available2016-06-22T18:54:39Z
dc.date.issued2016-01
dc.description.abstractForce depression (FD), the reduction of isometric force following active shortening, is a phenomenon of skeletal muscle that has received significant attention in biomechanical and physiological literature, yet the mechanisms underlying FD remain unknown. Recent experiments identified a slower rate of force redevelopment with increasing amounts of steady-state FD, suggesting that FD may be caused, at least in part, by a decrease in cross-bridge binding rate (Corr and Herzog, 2005; Koppes et al., 2014). Herein, we develop a cross-bridge based model of FD in which the binding rate function, f, decreases with the mechanical work performed during shortening. This modification incorporates a direct relationship between steady-state FD and muscle mechanical work (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008), and is consistent with a proposed mechanism attributing FD to stress-induced inhibition of cross-bridge attachments (Herzog, 1998; Maréchal and Plaghki, 1979). Thus, for an increase in mechanical work, the model should predict a slower force redevelopment (decreased attachment rate) to a more depressed steady-state force (fewer attached cross-bridges), and a reduction in contractile element stiffness (Ford et al., 1981). We hypothesized that since this modification affects the cross-bridge kinetics, a corresponding model would be able to account for both transient and steady-state FD behaviors. Comparisons to prior experiments (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008) show that both steady-state and transient aspects of FD, as well as the relationship of FD with respect to speed and amplitude of shortening, are well captured by this model. Thus, this relatively simple cross-bridge based model of FD lends support to a mechanism involving the inhibition of cross-bridge binding, and indicates that cross-bridge kinetics may play a critical role in FD.en_US
dc.description.refereedYesen_US
dc.identifier.citationCorr, D. T., & Herzog, W. (2016). A cross-bridge based model of force depression: Can a single modification address both transient and steady-state behaviors?. Journal of biomechanics, 49(5), 726-734.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/29052
dc.identifier.urihttp://hdl.handle.net/1880/51445
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.departmentHuman Performance Laboratoryen_US
dc.publisher.facultyKinesiologyen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectmuscle modelen_US
dc.subjecthistory-dependent propertiesen_US
dc.subjectmechanical worken_US
dc.subjectcross-bridge inhibitionen_US
dc.subjectforce recoveryen_US
dc.titleA Cross-Bridge Based Model of Force Depression: Can a Single Modification Address both Transient and Steady-State Behaviours?en_US
dc.typejournal article
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