Identification of Prolactin-Regulated Factors Contributing to Breast Cancer-Mediated Osteoclastogenesis

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atmire.migration.oldid3690
dc.contributor.advisorShemanko, Carrie
dc.contributor.authorForsyth, Amanda Nicole
dc.date.accessioned2015-09-28T16:35:32Z
dc.date.available2015-11-20T08:00:42Z
dc.date.issued2015-09-28
dc.date.submitted2015en
dc.description.abstractHigh serum levels of prolactin increase risk of breast cancer as well as increase metastasis in breast cancer patients. Bone is a preferential site of breast cancer metastasis and breast tumors are known to secrete soluble factors that enhance bone breakdown by stimulating differentiation and maturation of osteoclasts. This project conducted gene and cytokine arrays to elucidate the mechanism by which prolactin contributes to breast cancer-mediated osteoclastogenesis. Here we demonstrate that sonic hedgehog is a prolactin-regulated cytokine in breast cancer cells and is part of the mechanism that induces osteoclast differentiation. Furthermore, sonic hedgehog is expressed more frequently in breast invasive carcinoma tissue than normal tissue, supporting its role in tumor progression and metastasis. This mechanism can lead to the development of novel therapies to help alleviate osteolysis experienced by breast cancer patients.en_US
dc.identifier.citationForsyth, A. N. (2015). Identification of Prolactin-Regulated Factors Contributing to Breast Cancer-Mediated Osteoclastogenesis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26422en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26422
dc.identifier.urihttp://hdl.handle.net/11023/2517
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subjectOncology
dc.titleIdentification of Prolactin-Regulated Factors Contributing to Breast Cancer-Mediated Osteoclastogenesis
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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