The Genomic Basis of Adaptive Response to Anthelmintic Treatment in Two Species of Parasitic Nematodes

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dc.contributor.advisorYeaman, Sam
dc.contributor.authorJasper, Russell
dc.contributor.committeememberWasmuth, James
dc.contributor.committeememberGilleard, John
dc.date2022-11
dc.date.accessioned2022-06-20T14:16:50Z
dc.date.available2022-06-20T14:16:50Z
dc.date.issued2022-06-08
dc.description.abstractDespite rapid increases in next-generation sequencing studies, relatively little is known about how often species evolve convergently at the genotypic level, using the same loci to respond to a similar selection pressure (hereafter, genotypic convergence). Here we investigate similar adaptive responses in two species of parasitic nematodes, H. contortus and T. circumcincta, and test for possible genotypic convergence between species. After treating populations on farms across Western Canada with antiparasitic drugs, either fenbendazole or ivermectin, we use whole genome shotgun sequencing to identify loci putatively involved in drug resistance in each species and test for genotypic convergence. Despite both species facing similar environments and selection pressures and showing similar resistance statuses, we found no evidence for polygenic genotypic convergence for resistance. Although the response to selection was not strongly repeated between species, we did identify six candidate genes for resistance which were repeated between species.en_US
dc.identifier.citationJasper, R. (2022). The Genomic Basis of Adaptive Response to Anthelmintic Treatment in Two Species of Parasitic Nematodes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39842
dc.identifier.urihttp://hdl.handle.net/1880/114758
dc.language.isoengen_US
dc.publisher.facultyScienceen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjecthaemonchus contortusen_US
dc.subjectteladorsagia circumcinctaen_US
dc.subjectanthelmintic resistanceen_US
dc.subjectgenotypic convergenceen_US
dc.subjectbenzimidazoleen_US
dc.subjectivermectinen_US
dc.subjectgenetic convergenceen_US
dc.subjectadaptationen_US
dc.subject.classificationBioinformaticsen_US
dc.subject.classificationEcologyen_US
dc.subject.classificationGeneticsen_US
dc.subject.classificationParasitologyen_US
dc.titleThe Genomic Basis of Adaptive Response to Anthelmintic Treatment in Two Species of Parasitic Nematodesen_US
dc.typemaster thesisen_US
thesis.degree.disciplineBiological Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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