Induction of Antiviral Response Against Avian Infectious Laryngotracheitis Virus Infection

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atmire.migration.oldid3292
dc.contributor.advisorCareem, Faizal
dc.contributor.advisorCzub, Markus
dc.contributor.authorThapa, Simrika
dc.date.accessioned2015-06-09T21:24:44Z
dc.date.available2015-11-20T08:00:30Z
dc.date.issued2015-06-09
dc.date.submitted2015en
dc.description.abstractToll-like receptors (TLRs) recognize pathogen associated molecular patterns (PAMPs). The PAMPs that act as ligands for TLRs prompt downstream signalling leading to antimicrobial effects. However, the details of antiviral responses of lipotechoic acid (LTA) and CpG DNA, which act as ligands for TLR-2 and -21 respectively, elicited against avian viruses are scarce. We investigated whether in ovo delivery of LTA and CpG DNA induces antiviral responses against infectious laryngotracheitis virus (ILTV) infection in chickens. We found that in ovo delivery of these two ligands reduces ILTV infections in lungs pre- and post-hatch. However, only CpG DNA could reduce mortality and morbidity due to ILTV infection encountered post-hatch. The expression of IL-1β mRNA and increase of macrophage numbers in lungs were found to be correlates of observed antiviral responses. Thus, LTA and CpG DNA can be candidate TLR ligands worthy of further investigation for the control of ILTV infection in chickens.en_US
dc.identifier.citationThapa, S. (2015). Induction of Antiviral Response Against Avian Infectious Laryngotracheitis Virus Infection (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26508en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26508
dc.identifier.urihttp://hdl.handle.net/11023/2290
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectVeterinary Science
dc.subjectVirology
dc.subjectImmunology
dc.subject.classificationIn ovoen_US
dc.subject.classificationtoll-like receptor-2 and -21en_US
dc.subject.classificationLTAen_US
dc.subject.classificationCpG-motif containing synthetic DNAen_US
dc.subject.classificationinfectious laryngotracheitis virusen_US
dc.subject.classificationchickenen_US
dc.titleInduction of Antiviral Response Against Avian Infectious Laryngotracheitis Virus Infection
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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