fMRI techniques to investigate the functional recovery of individual patients following ischemic stroke

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dc.contributor.advisorGoodyear, Bradley
dc.contributor.authorDouglas, Erin Ashley
dc.date.accessioned2017-12-18T20:59:55Z
dc.date.available2017-12-18T20:59:55Z
dc.date.issued2005
dc.descriptionBibliography: p. 79-94en
dc.description.abstractRecently, functional magnetic resonance imaging (fMRI) has been used to investigate recovery of function post-stroke; however, it has not been implemented clinically due to the variability of measurements taken from individuals across imaging sessions. In this project, it was demonstrated that brain activity measurements based on a laterality index (LI) exhibits less variability than counting fMRI map pixels in a region of interest. It was also demonstrated that combining data from three to four runs of a specific task was required to detect <10% changes in LI across imaging sessions in individuals. Finally, T 2 * within ischemic tissue was elevated and more homogenous than in normal tissue, suggesting the need for an alternative to conventional fMRI. Overall, the results of this project provide the foundation for a clinically useful tool to investigate functional recovery of an individual patient, with the potential to impact on clinical care to help reduce long-term disability.
dc.format.extentxiv, 97 leaves : ill. ; 30 cm.en
dc.identifier.citationDouglas, E. A. (2005). fMRI techniques to investigate the functional recovery of individual patients following ischemic stroke (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/49en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/49
dc.identifier.urihttp://hdl.handle.net/1880/101050
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titlefMRI techniques to investigate the functional recovery of individual patients following ischemic stroke
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1567 520492084
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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