Inhibitory Neural Coding in the Deep Cerebellar Nuclei

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atmire.migration.oldid3290
dc.contributor.advisorTurner, Raymond
dc.contributor.authorDykstra, Steven
dc.date.accessioned2015-06-03T22:57:50Z
dc.date.available2015-06-22T07:00:52Z
dc.date.issued2015-06-03
dc.date.submitted2015en
dc.description.abstractThis study examines the response of Weak and Transient burst deep cerebellar nuclear (DCN) neurons when they are stimulated by physiological patterns of Purkinje cell inhibitory input in vitro. We also report the DCN neurons response to regular patterns of Purkinje cell firing defined by a CV2 analysis, as well as complex spike discharge. Currently the functional significance, and input parameters that generate rebound bursts in the DCN are unknown. Here we report that there are subtle differences in the Weak and Transient cell burst response suggesting the presence of differential coding by DCN neurons. Reverse correlation between DCN cell bursts and Purkinje cell input revealed an elevation-pause pattern of Purkinje cell firing triggers a rebound burst, while CV2-defined patterns and complex spikes failed to reliably trigger rebound responses. This work identifies a framework for future studies to investigate the relationship between Purkinje cell input and DCN output.en_US
dc.identifier.citationDykstra, S. (2015). Inhibitory Neural Coding in the Deep Cerebellar Nuclei (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26532en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/43870
dc.identifier.urihttp://hdl.handle.net/11023/2288
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationCerebellumen_US
dc.subject.classificationElectrophysiologyen_US
dc.subject.classificationCerebellar Nucleien_US
dc.titleInhibitory Neural Coding in the Deep Cerebellar Nuclei
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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