Anti-Müllerian Hormone & Cardiovascular Risk in Males with Chronic Kidney Disease

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dc.contributor.advisorDumanski, Sandra
dc.contributor.authorLarsen, Nicole
dc.contributor.committeememberFoong, Shu
dc.contributor.committeememberTyrone, Harrison
dc.date2024-11
dc.date.accessioned2024-10-07T15:28:40Z
dc.date.available2024-10-07T15:28:40Z
dc.date.issued2024-10-02
dc.description.abstractCardiovascular disease (CVD) is the leading cause of death globally and individuals living with chronic kidney disease (CKD) have an exceptionally high cardiovascular risk. Males living with CKD experience a disproportionately high risk of CVD mortality compared to females living with CKD. Reduced anti-Müllerian hormone (AMH), a hormone involved in sex differentiation and fertility, has been previously associated with CVD risk in healthy males and females, as well as in females living with CKD. However, whether AMH is linked to CVD in the high-risk population of males living with CKD is yet unknown. The aim of this exploratory cross-sectional study was to estimate the association between AMH and arterial stiffness, a validated predictor of CVD, in males living with CKD. Self-identified adult male individuals were recruited from Nephrology clinics in Calgary, Alberta, Canada. Individuals were included if they had a diagnosis of CKD (i.e. kidney damage or estimated glomerular filtration rate <60 ml/min/1.73 m2 for >3 months) and exclusion criteria included: 1) history of a major cardiovascular event, 2) history of any medical condition known to impact testicular function, and 3) current use of exogenous hormone therapy. Participant demographic information, medical history, physical examination, and laboratory data were collected alongside serum AMH levels, measured with a validated immunoassay. Using standardized protocols, pulse wave velocity (PWV) and aortic augmentation index (AIx) were measured to estimate arterial stiffness. Multivariable linear regression analyses assessed the relationship between AMH and each measure of arterial stiffness. Thirty-eight participants were recruited (29% early stage CKD, 42% advanced-stage CKD, 18% CKD treated with dialysis, 11% CKD treated with transplantation) with a median age of 44 years (IQR: 27). Age-adjusted models estimated the relationship between AMH and each measure of arterial stiffness to be statistically significant, though age was the primary driver of each relationship. Studies with larger sample sizes are needed to examine this further in addition to investigate other sex-specific cardiovascular risk factors for males living with CKD.
dc.identifier.citationLarsen, N. (2024). Anti-Müllerian hormone & cardiovascular risk in males with chronic kidney disease (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/119949
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectkidney
dc.subjectrenal
dc.subjecthormone
dc.subjectchronic kidney disease
dc.subjectmale reproductive health
dc.subjectcardiovascular health
dc.subjectcardiovascular
dc.subjectAMH
dc.subjectAnti-Müllerian Hormone
dc.subject.classificationEducation--Sciences
dc.titleAnti-Müllerian Hormone & Cardiovascular Risk in Males with Chronic Kidney Disease
dc.typemaster thesis
thesis.degree.disciplineMedicine – Medical Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
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