Lubricin Binds to and Regulates Toll-like Receptor (TLR) Activity
| atmire.migration.oldid | 3753 | |
| dc.contributor.advisor | Krawetz, Roman | |
| dc.contributor.advisor | Schmidt, Tannin | |
| dc.contributor.author | Iqbal, Shah | |
| dc.date.accessioned | 2015-10-01T22:11:01Z | |
| dc.date.available | 2015-11-20T08:00:43Z | |
| dc.date.issued | 2015-10-01 | |
| dc.date.submitted | 2015 | en |
| dc.description.abstract | In this study, lubricin, a protein involved in the lubrication of joints, was discovered to bind to and activate toll-like receptors (TLR). Since TLRs are a major component of the innate immune system, this suggests that lubricin may also play a role in the regulation of the inflammatory response. We attempted to elucidate whether lubricin has a pro- or anti-inflammatory role in the joint following TLR binding. To determine if lubricin-TLR interaction could be playing a role in Osteoarthritis (OA), we examined the cytokine secretions of OA fibroblasts treated with lubricin and demonstrated a potentially anti-inflammatory effect. Furthermore, in vivo studies demonstrated lubricin’s ability to mitigate pain, joint damage, and inflammation following an injury in a rat OA model. The experiments presented in this thesis suggest that lubricin could have anti-inflammatory effects when binding to TLRs at the cellular and tissue level. | en_US |
| dc.identifier.citation | Iqbal, S. (2015). Lubricin Binds to and Regulates Toll-like Receptor (TLR) Activity (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26802 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/26802 | |
| dc.identifier.uri | http://hdl.handle.net/11023/2586 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Biology--Cell | |
| dc.subject | Biology--Molecular | |
| dc.subject.classification | Lubricin | en_US |
| dc.subject.classification | Toll-like Receptor | en_US |
| dc.subject.classification | Osteoarthritis | en_US |
| dc.title | Lubricin Binds to and Regulates Toll-like Receptor (TLR) Activity | |
| dc.type | master thesis | |
| thesis.degree.discipline | Biomedical Engineering | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |