Contractile Properties of Cardiac Muscle Following Increasing Doses of Chronic Exercise Training and Overtraining in Rats

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atmire.migration.oldid4904
dc.contributor.advisorHerzog, Walter
dc.contributor.authorBoldt, Kevin
dc.contributor.committeememberMacIntosh, Brian
dc.contributor.committeememberSyme, Doug
dc.contributor.committeememberTyberg, John
dc.date.accessioned2016-09-19T22:09:25Z
dc.date.available2016-09-19T22:09:25Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe positive effects of chronic endurance exercise training on health and performance have been well documented. However, these positive effects have been evaluated primarily at the structural level, and it remains poorly understood how the heart muscle adapts mechanically to exercise training. In order to gain some understanding, we subjected three-month-old Sprague-Dawley rats to treadmill running for eleven weeks at one of three exercise volumes (moderate, high, and overtraining). Following training, hearts were excised and mechanical testing was completed on skinned trabecular bundles. Animals in the overtraining group experienced a significant loss in body mass, a withdrawal from food and drink, and became less active. The control, moderate, and high duration groups responded with a dose-dependent increase in heart mass and passive stresses, with no difference in active stress production. These trends were all reversed in the overtrained animals, despite presenting the greatest fitness on a graded treadmill test.en_US
dc.identifier.citationBoldt, K. (2016). Contractile Properties of Cardiac Muscle Following Increasing Doses of Chronic Exercise Training and Overtraining in Rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25445en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25445
dc.identifier.urihttp://hdl.handle.net/11023/3311
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectPhysiology
dc.subjectRehabilitation and Therapy
dc.subjectEngineering--Biomedical
dc.subject.classificationAerobic Exerciseen_US
dc.subject.classificationCardiovascular Physiologyen_US
dc.subject.classificationSprague Dawley Ratsen_US
dc.subject.classificationExercise Physiologyen_US
dc.subject.classificationBiomechanicsen_US
dc.titleContractile Properties of Cardiac Muscle Following Increasing Doses of Chronic Exercise Training and Overtraining in Rats
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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