Simultaneous Intracranial EEG-fMRI for the Study of Epilepsy in Humans at 3.0 T

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dc.contributor.advisorFederico, Paolo
dc.contributor.authorBeers, Craig
dc.date.accessioned2015-07-20T21:37:46Z
dc.date.embargolift10000-01-01
dc.date.issued2015-07-20
dc.date.submitted2015en
dc.description.abstractNeuroimaging plays in an important role in the diagnosis and treatment of epilepsy. In this work, a novel multi-modal technique for imaging the hemodynamic correlates of epileptic activity is explored. Simultaneous intracranial electroencephalography functional magnetic resonance imaging (iEEG-fMRI) combines the temporal precision of intracranial EEG with the high spatial resolution of fMRI. Applying this technique in patients with epilepsy, it was found the fMRI signal changes associated with interictal epileptiform discharges (IEDs) are patient-specific rather than consistent across subjects, implying that analyses of iEEG-fMRI data should allow for this variability through flexible analysis methods. In addition, significant fMRI activity was found adjacent to the electrode generating the IEDs in the majority of patients studied. It was determined that a minimum of 30 IEDs are necessary to detect fMRI activity near the active electrode, and the addition of more discharges to the analysis eliminates non-IED related noise providing more precise localization. Lastly, focusing exclusively on patients with mesial temporal lobe IEDs, two distinct patterns of fMRI activity were found: fMRI activity primarily localized to the active mesial temporal lobe, and widespread bilateral fMRI activity throughout the cortex. Notably, the patients with widespread activity were found to have fewer secondarily generalized seizures implying that the widespread fMRI activity may act to inhibit these seizures. In summary, simultaneous iEEG-fMRI is a viable technique for the study of epilepsy and may aid in the localization of the source of seizures and provide new insight into the networks involved in epileptic activity.en_US
dc.description.embargotermsindefiniteen_US
dc.identifier.citationBeers, C. (2015). Simultaneous Intracranial EEG-fMRI for the Study of Epilepsy in Humans at 3.0 T (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27790en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27790
dc.identifier.urihttp://hdl.handle.net/11023/2359
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subjectRadiology
dc.subject.classificationEpilepsyen_US
dc.subject.classificationEEGen_US
dc.subject.classificationfMRIen_US
dc.titleSimultaneous Intracranial EEG-fMRI for the Study of Epilepsy in Humans at 3.0 T
dc.typedoctoral thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.item.requestcopytrue
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