Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: a randomized clinical trial
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2012
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Abstract
There is a paucity of evidence to guide the management of febrile, critically ill patients without acute brain injury. This pilot, randomized clinical trial assessed the safety and feasibility of administering two different fever control strategies in critically ill adults. The biologic response to fever control was also assessed through analysis of several inflammatory mediators. Of the 179 patients screened for enrolment, 14 were randomized to the aggressive treatment group and 12 to the permissive group. The most common reason for exclusion from the trial was the presence of liver disease (22.2%). There were no significant differences in any of the markers of safety, and the fever control strategies did not appreciably influence the biology of fever. The most notable finding was a reduced number of patients with fever compared to that expected (31 % ). This impacted study participant recruitment and will affect the feasibility of completing a larger phase III study.
Description
Bibliography: p. 71-85
Includes copies of ethics approvals and copyright permissions. Original copies with original Partial Copyright Licence.
Includes copies of ethics approvals and copyright permissions. Original copies with original Partial Copyright Licence.
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Citation
Niven, D. J. (2012). Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: a randomized clinical trial (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4740