An experimental investigation into the vortex induced vibrations (VIV) of a circular cylinder under scour conditions was conducted. These conditions replicate river crossings of exposed pipelines. The thesis focuses on developing a model to predict the VIV response, and the characterization and flow evolution of the scour VIV response. The development of the model involves the calibration of a coupled two-equation model for a large VIV dataset from a one degree of freedom (1DOF) elastically mounted rigid cylinder in an open free stream that spans across a range of mass, damping, and flow velocities. This experiment was conducted in a water channel where cylinder displacement and force data were collected. The model adequately predicts the lock-in reduced velocity range and oscillation amplitudes. Its empirical coefficients are related to the mass, damping, and flow velocity, improving the prediction capability over previous models. A second data set was collected to address the characterization of VIV response and flow development under scour conditions. In particular, the experiments had one structural configuration with the 1DOF cylinder placed adjacent to different rigid flat and curved boundaries based on the profiles found in past scour studies. The collected data includes displacement, force, and Particle Image Velocity (PIV) measurements across a wide range of flow velocities. The data was processed to produce oscillation amplitude and lift responses, oscillation frequency contour maps, and a Low Order Representation (LOR) of the flow field through a Proper Orthogonal Decomposition (POD) analysis. The results show that the boundary modifies the VIV response in terms of lock-in range, oscillation amplitude, lift, and the appearance of new regimes when compared to the open free stream case. The LOR flow fields reveal the boundary layer coupling with the formation and shedding timing of the cylinder’s vortices, leading to the changes in the response. The results of this investigation aid in understanding the possible oscillation characteristics that submerged structures such as exposed pipelines in riverbeds exhibit. These characteristics inform the design and monitoring of these systems by relating the flow and structural conditions to the expected oscillation response.