Neuronal avalanche dynamics and criticality in neuronal cultures

Yaghoubi, Mohammad Hassan

Neuronal avalanche dynamics and criticality in neuronal cultures

dc.contributor.advisor	Davidsen, Jörn
dc.contributor.author	Yaghoubi, Mohammad Hassan
dc.contributor.committeemember	Hobill, David W.
dc.contributor.committeemember	Simon, Ch. H.
dc.contributor.committeemember	Sotero Díaz, Roberto C.
dc.date	2019-02
dc.date.accessioned	2019-01-03T17:00:11Z
dc.date.available	2019-01-03T17:00:11Z
dc.date.issued	2018-12-27
dc.description.abstract	The brain is often thought to be organized in a way that it optimizes its information processing and storage capabilities, supported by studies indicating that neuronal networks self-organize to a critical state. This is characterized by the emergence of scale-free statistics in neuronal avalanches close to those predicted by mean-field theory, suggesting that neuronal avalanches propagate in a tree-like network. Here, we use optical imaging techniques to study neuronal avalanches in different preparation of neuronal cultures and different dynamical regimes. We present an experimental case study where the avalanche statistics is significantly different from mean-field, suggesting that feed-back loops play a leading role in propagation of neuronal avalanches. Another phenomenon is that cortical and hippocampal neurons alternate between high and low activity regimes (up and down states) characterized by distinct firing rates. In contrast with previous theoretical works, our experimental findings suggest both states exhibit scale-free behavior with different intrinsic time scales.	en_US
dc.identifier.citation	Yaghoubi, M. H. (2018). Neuronal avalanche dynamics and criticality in neuronal cultures (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/35680
dc.identifier.uri	http://hdl.handle.net/1880/109405
dc.language.iso	en	en_US
dc.publisher.faculty	Science	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject.classification	Neuroscience	en_US
dc.subject.classification	Physics	en_US
dc.title	Neuronal avalanche dynamics and criticality in neuronal cultures	en_US
dc.type	master thesis	en_US
thesis.degree.discipline	Physics & Astronomy	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Master of Science (MSc)	en_US
ucalgary.item.requestcopy	true