Numerical Modeling of the Effects of Magnetic Field on Drug Transport for the Optimization of Drug-Eluting Stents

Vahedi, Seyed Masoud

Numerical Modeling of the Effects of Magnetic Field on Drug Transport for the Optimization of Drug-Eluting Stents

dc.contributor.advisor	Azaiez, Jalel
dc.contributor.author	Vahedi, Seyed Masoud
dc.contributor.committeemember	Clarke, Matthew Alexander
dc.contributor.committeemember	Hu, Jinguang
dc.date	2024-11
dc.date.accessioned	2024-05-09T17:40:14Z
dc.date.available	2024-05-09T17:40:14Z
dc.date.issued	2024-05-08
dc.description.abstract	This in-silico study investigates the impact of Magnetic Field (MF) on drug release from Drug-Eluting Stents (DESs) and its transport through the coronary arterial wall. Utilizing continuum modeling of mass balance, governing equations for both the polymer and media layers were developed based on porous media theory. These equations were then nondimensionalized, discretized, and then solved numerically using the Finite Volume Method (FVM). The findings reveal a significant increase in the concentration of drug particles near the stent strut. This increased concentration of free drug enhances its availability for both types of drug receptors, facilitating absorption and distribution over a wider area. Additionally, the positive influence of the MF on the velocity field extends beyond the tissue, leading to a delay in drug depletion on the polymer side. The counterintuitive simultaneous increase in dissolved drug in both the polymer and media layers was observed, attributed to drug mass fluxes through the polymer topcoat layer and the top layer of the media, where the drug exits the computational domain. Furthermore, both the rates of media layer filling and depletion decrease for a while in the presence of the MF, which is advantageous. However, a short period resembling conditions without the MF occurs after the decrease. Interestingly, mass flux rates higher than those without the MF result in a reversal of this trend. Experiencing this undesirable increase in drug depletion does not negate the favorable effect of the MF, as drug accumulation in the tissue has already begun during the initial stages of drug release. The maximum averaged concentrations of free drug in the tissue and dissolved drug in the polymer increase nonlinearly with MF strength, with a more pronounced effect observed in the polymer. Moreover, the time at which the tissue reaches its maximum drug content occurs earlier with increasing MF strength, while the dissolved phase experiences a delayed peak. The effect of the MF on drug particle transport was further characterized by determining the center of mass, revealing a non-monotonic variation over time comprising two linear stages. Increasing MF strength is associated with a stronger tendency for the center of mass to be closer to the top surface of the polymer. Overall, this study demonstrates that the presence of an MF can enhance the efficiency of polymer drug release kinetics, potentially aiding in the development of DESs with smaller strut and thinner coating layer, thus reducing stent failure. Moreover, the study identifies values for equivalent polymer thickness and width corresponding to different MF intensities.
dc.identifier.citation	Vahedi, S. M. (2024). Numerical modeling of the effects of magnetic field on drug transport for the optimization of drug-eluting stents (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/118721
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Convection-Diffusion-Reaction
dc.subject	Porous Media
dc.subject	Numerical Simulation
dc.subject	Non-uniform Magnetic Field
dc.subject	Implant Assisted-magnetic Drug Targeting
dc.subject	Stent Size Optimization
dc.subject	Tissue Permeability
dc.subject	Blood Viscosity
dc.subject.classification	Chemistry--Pharmaceutical
dc.subject.classification	Fluid and Plasma
dc.subject.classification	Engineering--Biomedical
dc.subject.classification	Engineering--Chemical
dc.title	Numerical Modeling of the Effects of Magnetic Field on Drug Transport for the Optimization of Drug-Eluting Stents
dc.type	master thesis
thesis.degree.discipline	Engineering – Chemical & Petroleum
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I require a thesis withhold – I need to delay the release of my thesis due to a patent application, and other reasons outlined in the link above. I have/will need to submit a thesis withhold application.