Magnetic resonance spectroscopy in Pediatric Concussion: Examining longitudinal and multisite data

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dc.contributor.advisorHarris, Ashley
dc.contributor.authorLa, Parker Lanhuy
dc.contributor.committeememberYeates, Keith
dc.contributor.committeememberDebert, Chantel
dc.contributor.committeememberBrooks, Brian
dc.date2023-02
dc.date.accessioned2023-10-24T16:28:16Z
dc.date.available2023-10-24T16:28:16Z
dc.date.issued2023-10-19
dc.description.abstractMillions of concussions occur annually in children and youths. Though metabolic disturbance has been shown to be present in adult concussion, there is less research and evidence of these same effects in pediatric groups. Using Magnetic Resonance Spectroscopy (MRS), we can study neurometabolites that may be altered following pediatric concussion. With increasing interest in MRS to study concussion and other clinical conditions, there is increased importance to understand differences between analysis software and how to harmonize multi-site/vendor studies to increase sample sizes. My thesis aims to improve our understanding of the metabolite changes in pediatric concussion and associated technical moderators in multisite MRS studies. To accomplish this goal, my work examines MRS data from the Advancing Concussion Assessment in Pediatrics (A-CAP) study, which recruited pediatric concussion participants and an orthopedic injury (OI) control group. The results found: 1) No differences in neurometabolites at 12-days post-injury in children with concussion and OI, 2) No significant differences in metabolite trajectories between those with and without concussion symptoms over time (12-days, 3-month, 6-month), 3) Significant decreases in tCho in those with somatic symptoms in comparison to OI controls at 3-months, 4) Large vendor effects and different statistical methods to account for multisite data could yield different results, and 5) Software-related differences in metabolite quantification with associated bias, though clinical results were consistent. These investigations provide important context in pediatric concussion and neurometabolic activity in the short and long-term. Additionally, this work provides recommendations for how to control for multi-site/vendor and offer a description of the biases and agreement between different MRS quantification software.
dc.identifier.citationLa, P. L. (2023). Magnetic resonance spectroscopy in pediatric concussion: examining longitudinal and multisite data (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/117429
dc.identifier.urihttps://doi.org/10.11575/PRISM/42272
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectConcussion
dc.subjectMulti-site
dc.subjectLongitudinal
dc.subjectPediatric
dc.subject.classificationRadiology
dc.subject.classificationNeuroscience
dc.titleMagnetic resonance spectroscopy in Pediatric Concussion: Examining longitudinal and multisite data
dc.typedoctoral thesis
thesis.degree.disciplineMedicine – Medical Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
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