Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate

dc.contributor.authorMaine, Eleanor M.en
dc.contributor.authorHansen, Dave D.en
dc.contributor.authorSpringer, Deborahen
dc.contributor.authorVought, Valarie E.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.facultyFaculty of Scienceen
dc.contributor.institutionUniversity of Calgaryen
dc.date.accessioned2006-08-15T16:48:31Z
dc.date.available2006-08-15T16:48:31Z
dc.date.issued2004-10
dc.descriptionCopyright 2004 by the Genetics Society of America DOI: 10.1534/genetics.104.029355en
dc.description.abstractIn the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling. Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways, which function redundantly to promote meiosis and/or inhibit proliferation. Activation of the germline Notch-type receptor, GLP-1, ultimately inhibits the activities of the GLD-1 and GLD-2 pathways. We previously identified several ego (enhancer of glp-1) genes that promote germline proliferation and interact genetically with the GLP-1 signaling pathway. Here, we show that atx-2 is an ego gene. Our data suggest that ATX-2 is not a positive regulator of the GLP-1 signaling pathway and GLP-1 signaling is not the sole positive regulator of ATX-2 activity. Moreover, our data indicate that GLP-1 must have an additional function, which may be to repress activity of a third meiotic entry pathway that would work in parallel with the GLD-1 and GLD-2 pathways. In addition to its role in proliferation, ATX-2 acts downstream of FOG-2 to promote the female germline fate.en
dc.description.refereedyesen
dc.format.extent418359 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationEleanor M. Maine, Dave Hansen, Deborah Springer, Valarie E. Vought "Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate" Genetics 168: 817–830 (October 2004)en
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35119
dc.identifier.issn0016-6731
dc.identifier.urihttp://hdl.handle.net/1880/43438
dc.language.isoenen
dc.publisherGenetics Society of Americaen
dc.publisher.urlhttp://www.genetics.org/
dc.subjectBiologyen
dc.titleCaenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fateen
dc.typejournal article
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