Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate
dc.contributor.author | Maine, Eleanor M. | en |
dc.contributor.author | Hansen, Dave D. | en |
dc.contributor.author | Springer, Deborah | en |
dc.contributor.author | Vought, Valarie E. | en |
dc.contributor.department | Biological Sciences | en |
dc.contributor.faculty | Faculty of Science | en |
dc.contributor.institution | University of Calgary | en |
dc.date.accessioned | 2006-08-15T16:48:31Z | |
dc.date.available | 2006-08-15T16:48:31Z | |
dc.date.issued | 2004-10 | |
dc.description | Copyright 2004 by the Genetics Society of America DOI: 10.1534/genetics.104.029355 | en |
dc.description.abstract | In the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling. Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways, which function redundantly to promote meiosis and/or inhibit proliferation. Activation of the germline Notch-type receptor, GLP-1, ultimately inhibits the activities of the GLD-1 and GLD-2 pathways. We previously identified several ego (enhancer of glp-1) genes that promote germline proliferation and interact genetically with the GLP-1 signaling pathway. Here, we show that atx-2 is an ego gene. Our data suggest that ATX-2 is not a positive regulator of the GLP-1 signaling pathway and GLP-1 signaling is not the sole positive regulator of ATX-2 activity. Moreover, our data indicate that GLP-1 must have an additional function, which may be to repress activity of a third meiotic entry pathway that would work in parallel with the GLD-1 and GLD-2 pathways. In addition to its role in proliferation, ATX-2 acts downstream of FOG-2 to promote the female germline fate. | en |
dc.description.refereed | yes | en |
dc.format.extent | 418359 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Eleanor M. Maine, Dave Hansen, Deborah Springer, Valarie E. Vought "Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate" Genetics 168: 817–830 (October 2004) | en |
dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/35119 | |
dc.identifier.issn | 0016-6731 | |
dc.identifier.uri | http://hdl.handle.net/1880/43438 | |
dc.language.iso | en | en |
dc.publisher | Genetics Society of America | en |
dc.publisher.url | http://www.genetics.org/ | |
dc.subject | Biology | en |
dc.title | Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte Fate | en |
dc.type | journal article |