An Exploration into the Non-Photic Influence of Acetylcholinesterase Inhibitors on Circadian Rhythms

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dc.contributor.advisorAntle, Michael C.
dc.contributor.authorJamani, Naila Feroz
dc.contributor.committeememberDyck, Richard H.
dc.contributor.committeememberSargin, Derya
dc.contributor.committeememberEpp, Jonathan Richard
dc.date2020-11
dc.date.accessioned2020-09-28T13:56:57Z
dc.date.available2020-09-28T13:56:57Z
dc.date.issued2020-09-24
dc.description.abstractWhile light is the dominant zeitgeber (“time giver”) for the circadian system, nonphotic cues, such as exercise and arousal, also affect circadian rhythmicity. Our lab has reported that cholinergic innervation of the suprachiasmatic nucleus arising from the basal forebrain is both necessary and sufficient for phase shifting circadian rhythms in a nonphotic manner. Therefore, the present study investigated a new avenue for modulating cholinergic activity in a less invasive manner by testing whether enhancing acetylcholine neurotransmission with acetylcholinesterase (AChE) inhibitors will cause nonphotic-like phase shifts of the circadian system. Three different AChE inhibitors were explored (Donepezil, Rivastigmine, and Tacrine) at varying doses. First, Syrian hamsters were housed in constant darkness (DD), and were administered an intraperitoneal (IP) injection of one of the AChE inhibitors or vehicle control in counterbalanced order six hours before their activity onset, a phase when nonphotic treatments elicit phase advances. The second hypothesis was that nonphotic phase shifts elicited by AChE inhibitor administration requires acetylcholine activity at the SCN. Hamsters were given a microinjection of either saline or the acetylcholine antagonist Atropine to the SCN 10 minutes prior to a CT6 injection of donepezil (10mg/kg). In experiment one, Donepezil at 10mg/kg had the most robust phase advances relative to the controls. In experiment two, the results were mixed with no significant differences were found between conditions, including the baseline measurement of Donepezil/control.en_US
dc.identifier.citationJamani, N. F. (2020). An Exploration into the Non-Photic Influence of Acetylcholinesterase Inhibitors on Circadian Rhythms (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38257
dc.identifier.urihttp://hdl.handle.net/1880/112598
dc.language.isoengen_US
dc.publisher.facultyArtsen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectAcetylcholineen_US
dc.subjectSuprachiasmatic Nucleusen_US
dc.subjectNon-photicen_US
dc.subjectCircadianen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPsychology--Behavioralen_US
dc.subject.classificationPsychology--Experimentalen_US
dc.titleAn Exploration into the Non-Photic Influence of Acetylcholinesterase Inhibitors on Circadian Rhythmsen_US
dc.typemaster thesisen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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