Facial Shape Variation in Humans

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atmire.migration.oldid6146
dc.contributor.advisorHallgrimsson, Benedikt
dc.contributor.advisorJamniczky, Heather
dc.contributor.authorLarson, Jacinda R.
dc.contributor.committeememberHarrop, Robertson
dc.contributor.committeememberRolian, Campbell
dc.date.accessioned2017-10-04T15:01:23Z
dc.date.available2017-10-04T15:01:23Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractThe human face is a highly variable feature. Facial shape variation is seen between and within multiple populations. However, the source of this variation is mostly unknown. Furthermore, phenotypic variation is observed within syndromes that display a unique craniofacial phenotype. Because of this inherent variation, facial shape has a large clinical important and diagnostic significance. To explore facial shape variation, I have conducted several studies that examine the role of morphological integration in producing coordinated shape changes in the face. In these studies, I hypothesized that the size of the face and skull are correlated with facial shape; and that dysmorphic patients will display different morphological relationships between parts of the face, when compared to controls. These hypotheses were tested in several groups; namely healthy controls, patients with non-syndromic cleft lip and/or palate, and patients with ectodermal dysplasia. While these conditions have different etiologies, genetics, inheritance, mechanism of development, and resultant facial shape, using both of these patient groups has allowed me to explore these hypotheses in starkly different phenotypic groups. My studies have shown that the allometric factors of facial shape variation are complex and overlapping. Size represents a relatively small proportion of facial shape variation in humans. Furthermore, different classifications of cleft phenotypes are crucial when deciphering covariance structure in cleft individuals. Collectively, these studies have furthered the knowledge of complex craniofacial phenotypes, and have extended the knowledge on how allometry affects human facial shapes.en_US
dc.identifier.citationLarson, J. R. (2017). Facial Shape Variation in Humans (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26141en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26141
dc.identifier.urihttp://hdl.handle.net/11023/4208
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnthropology
dc.subjectAnthropology--Physical
dc.subjectAnatomy
dc.subjectHealth Sciences
dc.subjectDentistry
dc.subjectMedicine and Surgery
dc.subject.otherphenotypic
dc.subject.othervariation
dc.subject.otherbirth
dc.subject.otherdefects
dc.subject.othercleft
dc.subject.otherlip
dc.subject.otherpalate
dc.subject.otherectodermal
dc.subject.otherdysplasia
dc.subject.othergeometric
dc.subject.othermorphometrics
dc.subject.otherTanzania
dc.subject.otherTanzanians
dc.subject.otherBantu
dc.subject.othercovariation
dc.subject.othercovariance
dc.titleFacial Shape Variation in Humans
dc.typedoctoral thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.item.requestcopytrue
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