Incidence and Risk Factors for Hyponatremia in Patients Newly Prescribed Citalopram

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dc.contributor.advisorNaugler, Christopher T.
dc.contributor.authorShysh, Andrea Christine
dc.contributor.committeememberSidhu, Davinder
dc.contributor.committeememberIsmail, Zahinoor
dc.date2019-06
dc.date.accessioned2019-04-29T20:13:36Z
dc.date.available2019-04-29T20:13:36Z
dc.date.issued2019-04-26
dc.description.abstractHyponatremia is a common and under-recognized adverse drug reaction of citalopram. This study aims to determine the incidence of hyponatremia and to identify risk factors in a large, population-based cohort initiating new prescriptions for citalopram. Following approval from the ethics review board, data were obtained from Alberta Information Network databases to identify patients with new citalopram prescriptions from 2010-2017, inclusive. Hyponatremia was defined as serum sodium level <135 mmol/L. Associations were determined by performing Cox regression with time-varying covariate analysis, with the development of hyponatremia as the dependent variable. This is the first large-scale, population-based study to explore risk factors, based solely on laboratory serum data, for the development of hyponatremia in patients initiating citalopram therapy. We report a 16.7% incidence of hyponatremia after starting citalopram treatment and significant risk factors include lower baseline sodium, concurrent thiazide diuretic use, older age, and male sex.en_US
dc.identifier.citationShysh, A. C. (2019). Incidence and Risk Factors for Hyponatremia in Patients Newly Prescribed Citalopram (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36418
dc.identifier.urihttp://hdl.handle.net/1880/110236
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectHyponatremiaen_US
dc.subjectCitalopramen_US
dc.subjectRisk Factoren_US
dc.subject.classificationEpidemiologyen_US
dc.subject.classificationPharmacologyen_US
dc.subject.classificationPublic Healthen_US
dc.titleIncidence and Risk Factors for Hyponatremia in Patients Newly Prescribed Citalopramen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrue
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